Early initiation of antibiotic therapy and short-term outcomes in preterm infants: a single-centre retrospective cohort analysis.

Natascha Köstlin-GilleLina Maria Serna-HiguitaCaren BubserJoerg ArandLaura HaagChristoph E SchwarzMartin HeidekingChristian F PoetsChristian Gille

Published in: Archives of disease in childhood. Fetal and neonatal edition (2023)

Very early initiation of antibiotic therapy was associated with an increased risk of BPD. Due to the study design, no conclusions on causality can be drawn. If confirmed, our data suggest that an improved identification of infants at low risk of early-onset sepsis is needed to reduce antibiotic exposure.

Keyphrases

early onset
preterm infants
late onset
intensive care unit
acute kidney injury
cross sectional
electronic health record
low birth weight
machine learning
stem cells
emergency department
mesenchymal stem cells
artificial intelligence