Novel Liver Injury Phenotypes and Outcomes in Clinical Trial Participants with Pulmonary Hypertension.
Jacqueline V ScottJude MoutchiaRobin L McClellandNadine Al-NaamaniEthan WeinbergHarold I PalevskyJasleen MinhasDina K ApplebyAkaya SmithSteven C PuglieseCorey E VentetuoloSteven M KawutPublished in: American journal of respiratory and critical care medicine (2024)
Liver injury was associated with adverse outcomes in patients with PAH and CTEPH. Randomization to active treatment had beneficial effects on liver health compared to placebo. The role of liver disease (often subclinical) in determining outcomes warrants prospective studies.
Keyphrases
- liver injury
- drug induced
- clinical trial
- pulmonary hypertension
- healthcare
- public health
- mental health
- double blind
- open label
- phase iii
- randomized controlled trial
- pulmonary arterial hypertension
- metabolic syndrome
- health information
- phase ii
- study protocol
- risk assessment
- coronary artery
- human health
- glycemic control