Transcription factor TEAD4 could activate PCSK9 to promote the stemness of STAD cells through FAM. These results added weight to the assumption that TEAD4/PCSK9 axis has the potential to be the therapeutic target that inhibits cancer stem cell in STAD.
Keyphrases
- cancer stem cells
- transcription factor
- fatty acid
- stem cells
- low density lipoprotein
- induced apoptosis
- epithelial mesenchymal transition
- cell cycle arrest
- single cell
- squamous cell carcinoma
- cell therapy
- body mass index
- weight loss
- physical activity
- human health
- cell death
- locally advanced
- signaling pathway
- radiation therapy
- cell proliferation
- oxidative stress
- climate change
- pi k akt