Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors.
Florian ThibordDerek M KlarinJennifer A BrodyMing-Huei ChenMichael G LevinDaniel I ChasmanEllen L GoodeKristian HveemMaris Teder-LavingAngel Martinez-PerezDylan AïssiDelphine Daian-BacqShefali S VermaPradeep NatarajanPamela L LutseyGirish Nitin NadkarniPaul S de VriesGabriel Cuellar-PartidaBrooke N WolfordJack W PatteeCharles KooperbergSigrid Kufaas BrækkanRuifang Li-GaoNoémie SautCorriene SeptMarine GermainRenae L JudyKerri L WigginsSarah R PreisChristopher J O'DonnellKent D TaylorFranco GiulianiniMariza de AndradeTherese Haugdhal NøstAnne Boland-AugeJean Philippe EmpanaSatoshi KoyamaThomas C GillilandRon DoJennifer E HuffmanXin WangWei ZhouJosé Manuel SoriaJuan Carlos Carlos SoutoNathan D PankratzJeffery HaesslerKristian HindbergFrits Richard RosendaalConstance TurmanRobert OlasoRachel L KemberTraci M BartzJulie A LynchSusan R HeckbertSebastian M ArmasuBen Michael BrumptonDavid M SmadjaXavier JouvenIssei KomuroKatharine R ClaphamRuth J F LoosCristen J WillerMaria Sabater-LlealJames S PankowAlexander P ReinerVania M MorelliPaul M RidkerAstrid van Hylckama VliegJean-François DeleuzePeter KraftDaniel James Radernull nullKyung Min LeeBruce M PsatyAnne Heidi SkogholtJoseph EmmerichPierre SuchonStephen S RichHa My Thi VyWeihong TangRebecca D JacksonJohn-Bjarne HansenPierre-Emmanuel MorangeChristopher KabrhelDavid-Alexandre TrégouëtScott M DamrauerAndrew Danner JohnsonNicholas L SmithPublished in: Circulation (2022)
Our cross-ancestry GWAS meta-analyses identified new loci associated with VTE. These findings highlight new pathways to thrombosis and provide novel molecules that may be useful in the development of improved antithrombosis treatments.