Biomarker-guided intervention to prevent acute kidney injury after major surgery (BigpAK-2 trial): study protocol for an international, prospective, randomised controlled multicentre trial.

Thilo von Groote Alexander ZarbockStefano RomagnoliMarlies OstermannJavier Ripollés-MelchorAntoine Guillaume Schneider Wim VandenbergheCéline MonardSilvia De RosaLucia CattinTim RahmelMichael AdamzikDiego PariseAngel Candela-TohaJan Gerrit HaakerUlrich GöbelAlice BernardNuttha LumlertgulPaula Fernández-Valdes-BangoIrene Romero BhathalA Suarez-de-la-RicaJan LarmannGianluca VillaSavino SpadaroHinnerk WulfChristian ArndtChristian PutensenRaquel García-ÁlvarezTimo BrandenburgerAntonio SiniscalchiRichard EllerkmannFlorian EspeterChristian PorschenMahan SadjadiKhaschayar Saadat-GilaniRaphael WeissJoachim GerssJohn KellumAlexander Zarbocknull null

Published in: BMJ open (2023)

NCT04647396.

Keyphrases

study protocol
randomized controlled trial
acute kidney injury
clinical trial
phase iii
phase ii
minimally invasive
cardiac surgery
coronary artery bypass
open label
double blind