SOX2 Drives Bronchial Dysplasia in a Novel Organotypic Model of Early Human Squamous Lung Cancer.

Lúcia L CorreiaJo-Anne JohnsonPeter McErleanJulien BauerHassan FarahDoris M RasslRobert Campbell RintoulTariq SethiPaul LavenderEmma L RawlinsTrevor D LittlewoodGerard I EvanFrank M McCaughan

Published in: American journal of respiratory and critical care medicine (2017)

In the appropriate genetic and microenvironmental context, acute deregulation of SOX2 drives bronchial dysplasia. This confirms its oncogenic potential in human cells and affords novel insights into the impact of SOX2 deregulation. This model can be used to test therapeutic agents aimed at chemoprevention.

Keyphrases

transcription factor
stem cells
endothelial cells
high grade
respiratory failure
genome wide
low grade
dna methylation
human health
induced pluripotent stem cells
risk assessment
pluripotent stem cells