A novel somatostatin receptor ligand for human ACTH - and GH -secreting pituitary adenomas.
Daniela RegazzoSerena AvalloneCliona P MacSweeneyEugenia SergeevDavid HoweAlex GodwoodKirstie A BennettAlastair J H BrownMatt BarnesGianluca OcchiMattia BarbotDiego FaggianMaria Pia TropeanoMarco LosaGiovanni LasioCarla ScaroniFrancesca Pecori GiraldiPublished in: European journal of endocrinology (2024)
This first study on a novel somatostatin receptor 5-preferring ligand indicates that HTL0030310 can inhibit hormonal secretion in human ACTH- and GH-secreting pituitary adenomas. These findings suggest a potential new avenue for somatostatin ligands in the treatment of Cushing's disease and acromegaly.