Application of metabolomics to preeclampsia diagnosis.
B Fatemeh Nobakht M GhPublished in: Systems biology in reproductive medicine (2018)
PE: preeclampsia; sFlt-1: soluble FMS-like tyrosine kinase-1; PlGF: placental growth factor; GC-MS: gas chromatography-mass spectrometry; LC-MS: liquid chromatography-mass spectrometry; NMR: nuclear magnetic resonance spectroscopy; HMDB: human metabolome database; RCT: randomized control trial; e-PE: early-onset PE; l-PE: late-onset PE; PLS-DA: partial least-squares-discriminant analysis; CRL: crown-rump length; UtPI: uterine artery Doppler pulsatility index; BMI: body mass index; MAP: mean arterial pressure; OS: oxidative stress; PAPPA: plasma protein A; FTIR: Fourier transform infrared; BCAA: branched chain amino acids; Arg: arginine; NO: nitric oxide.
Keyphrases
- early onset
- late onset
- tyrosine kinase
- mass spectrometry
- growth factor
- liquid chromatography
- body mass index
- nitric oxide
- gas chromatography mass spectrometry
- amino acid
- epidermal growth factor receptor
- oxidative stress
- gas chromatography
- high resolution
- endothelial cells
- tandem mass spectrometry
- high resolution mass spectrometry
- solid phase extraction
- open label
- double blind
- high performance liquid chromatography
- magnetic resonance
- weight gain
- physical activity
- capillary electrophoresis
- nitric oxide synthase
- phase ii
- hydrogen peroxide
- clinical trial
- ischemia reperfusion injury
- ms ms
- blood flow
- pluripotent stem cells
- placebo controlled
- heat stress
- adverse drug