Understanding inconsistency in the results from observational pharmacoepidemiological studies: the case of antidepressant use and risk of hip/femur fractures.

Patrick C SouvereinVictoria Abbing-KarahagopianElisa MartinConsuelo HuertaFrancisco de AbajoHubert G M LeufkensGianmario CandoreYolanda AlvarezJim SlatteryMontserrat MiretGema RequenaMiguel J GilRolf H H GroenwoldRobert ReynoldsRaymond G SchliengerJohn W LogieMark C H de GrootOlaf H KlungelTjeerd P van StaaToine C G EgbertsMarie L De BruinHelga Gardarsdottir

Published in: Pharmacoepidemiology and drug safety (2017)

We found a consistent increased risk of hip/femur fracture with current use of antidepressants across different databases and different designs. Applying similar pharmacoepidemiological study methods resulted in similar risks for TCA use and some variation for SSRI use. Some of these differences may express real (or natural) variance in the exposure-outcome co-occurrences.

Keyphrases

major depressive disorder
bone mineral density
total hip arthroplasty
finite element
human health
cross sectional
postmenopausal women
risk assessment
big data
body composition
climate change
deep learning
artificial intelligence
finite element analysis