Losartan in hospitalized patients with COVID-19 in North America: An individual participant data meta-analysis.

Leon Di StefanoMalathi RamDaniel O ScharfsteinTianjing LiPreeti KhanalSheriza N BakshNichol McBeeCharles D BengtsonAnne GadomskiMatthew GeriakMichael A PuskarichMatthias A SalatheAletta E SchutteChristopher J TignanelliJennifer VictoryBarbara E BiererDaniel F HanleyDaniel A Freilichnull null

Published in: Medicine (2023)

In this IPD meta-analysis of hospitalized COVID-19 patients, we found no convincing evidence for the benefit of losartan versus control treatment, but a higher rate of hypotension adverse events with losartan.

Keyphrases

angiotensin ii
systematic review
meta analyses
electronic health record
randomized controlled trial
big data
machine learning
replacement therapy
deep learning