Up-regulation of transient receptor potential vanilloid (TRPV) and down-regulation of brain-derived neurotrophic factor (BDNF) expression in patients with functional dyspepsia (FD).

Cynthia K Y CheungL L LanM KyawA D P MakA ChanY ChanJ C Y Wu

Published in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2017)

Despite lacking gastric mucosal inflammation, up-regulation of TRPV1 and TRPV2, down-regulation of BDNF were observed in FD patients. These suggest that immune alteration may contribute to the pathogenesis of FD without any previous infection.

Keyphrases

end stage renal disease
neuropathic pain
oxidative stress
poor prognosis
ejection fraction
newly diagnosed
prognostic factors
peritoneal dialysis
binding protein
risk assessment
climate change
ulcerative colitis
helicobacter pylori infection
helicobacter pylori