NR4A ablation improves mitochondrial fitness for long persistence in human CAR-T cells against solid tumors.
Kensuke NakagawaraMakoto AndoTanakorn SriratSetsuko Mise-OmataTaeko HayakawaMinako ItoKoichi FukunagaAkihiko YoshimuraPublished in: Journal for immunotherapy of cancer (2024)
NR4A factors regulate CAR-T cell persistence and stemness through mitochondrial gene expression, therefore NR4A is a highly promising target for the generation of superior CAR-T cells against solid tumors.
Keyphrases
- gene expression
- oxidative stress
- induced apoptosis
- endothelial cells
- stem cells
- cell cycle arrest
- single cell
- dna methylation
- physical activity
- cell therapy
- body composition
- epithelial mesenchymal transition
- endoplasmic reticulum stress
- pluripotent stem cells
- radiofrequency ablation
- cell proliferation
- catheter ablation