TCRs with segment TRAV9-2 or a CDR3 histidine are overrepresented among nickel-specific CD4+ T cells.
Marina Aparicio-SotoFranziska RiedelMelanie LeddermannPetra BacherAlexander ScheffoldHeiner KuhlBernd TimmermannDmitriy M ChudakovSonja MolinMargitta WormGuido HeineHermann-Josef ThierseAndreas LuchKatherina SiewertPublished in: Allergy (2020)
Induced CD154 expression represents a reliable method to study nickel-specific CD4+ T cells. TCRs with particular features respond in all donors, while strongly increased blood frequencies indicate nickel allergy for some donors. Our approach may be extended to other contact allergens for the further development of diagnostic and predictive in vitro tests.