Dermal fillers do not induce upregulation of NLRP3 inflammasomes or expression of inflammatory cytokines in granulomas.
Markus ReinholzBenjamin M Clanner-EngelshofenMarkus V HepptEnklajd MarselaYoshio KawakamiLuitgard G WiestLars E FrenchWilhelm StolzGerd G GauglitzPublished in: Journal of cosmetic dermatology (2020)
No increased inflammasome activation could be observed; however, filler granulomas were infiltrated with granulocytes and macrophages. Therefore, we speculate that an unspecific immune response might be the key player in the formation of filler granuloma.