Role of miR-15a-5p and miR-199a-3p in the inflammatory pathway regulated by NF-κB in experimental and human atherosclerosis.

Paula González-LópezMarta Álvarez-VillarrealRubén Ruiz-SimónAndrea R López-PastorMelina Vega de CenigaLeticia EsparzaJosé L Martín-VenturaOscar Escribano Almudena Gómez-Hernández

Published in: Clinical and translational medicine (2023)

Our results suggest that the decrease of miR-199a-3p and miR-15a-5p in vascular samples from human and experimental atherosclerosis could be involved in the NF-κB activation pathway, as well as in ox-LDL uptake by VSMCs, contributing to inflammation and progression atherosclerosis. Finally, miR-15a-5p could be used as a novel diagnostic biomarker for advanced atherosclerosis.

Keyphrases

oxidative stress
cardiovascular disease
endothelial cells
signaling pathway
lps induced
induced pluripotent stem cells
pluripotent stem cells
type diabetes
cell proliferation
toll like receptor
low density lipoprotein