Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy.
Monica XiongChao WangMaud GratuzeFareeha SaadiXin BaoMegan E BoschChoonghee LeeHong JiangJavier Remolina SerranoErnesto R GonzalesMichal KipnisDavid M HoltzmanPublished in: Molecular neurodegeneration (2023)
In a mouse model of CAA, the reduction of APOE4 derived specifically from astrocytes, despite increased fibrillar Aβ deposition in the vasculature, is sufficient to reduce Aβ-mediated gliosis and cerebrovascular dysfunction.