David M Holtzman (David Holtzman)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 108

Top Venues

The Journal of experimental medicine

Science translational medicine

Science (New York, N.Y.)

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Mika P Cadiz, Katelin A Gibson, Kennedi T Todd, David G Nascari, Nashali Massa, Meredith T Lilley, Kimberly C Olney, Md Mamun Al-Amin, Hong Jiang, David M Holtzman, John D Fryer
Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations. The Journal of experimental medicine 221 (2) (2024)
Jin-Chao Hou, Yun Chen, Zhangying Cai, Gyu Seong Heo, Carla M Yuede, Zuoxu Wang, Kent Lin, Fareeha Saadi, Tihana Trsan, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Yiyang Zhu, Nicole D Wagner, Nolan McLaughlin, Xinyi Cynthia Kuang, Alexander D Barrow, Dian Li, Yingyue Zhou, Shoutang Wang, Susan Gilfillan, Michael L Gross, Simone Brioschi, Yongjian Liu, David M Holtzman, Marco Colonna
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model. Science translational medicine 16 (741) (2024)
Francis Shue, Launia J White, Rachel D Hendrix, Jason D Ulrich, Rachel L Henson, William Knight, Yuka A Martens, Ni Wang, Bhaskar Roy, Skylar C Starling, Yingxue Ren, Chengjie Xiong, Yan W Asmann, Jeremy A Syrjanen, Maria Vassilaki, Michelle M Mielke, Jigyasha Timsina, Yun Ju Sung, Cruchaga Carlos, David M Holtzman, Guojun Bu, Ronald C Petersen, Michael G Heckman, Takahisa Kanekiyo
CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly. Science advances 10 (14) (2024)
Francis Shue, Launia J White, Rachel D Hendrix, Jason D Ulrich, Rachel L Henson, William Knight, Yuka A Martens, Ni Wang, Bhaskar Roy, Skylar C Starling, Yingxue Ren, Chengjie Xiong, Yan W Asmann, Jeremy A Syrjanen, Maria Vassilaki, Michelle M Mielke, Jigyasha Timsina, Yun Ju Sung, Cruchaga Carlos, David M Holtzman, Guojun Bu, Ronald C Petersen, Michael G Heckman, Takahisa Kanekiyo
CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly. Science advances 10 (14) (2024)
Chengjie Xiong, Jingqin R Luo, David A Wolk, Leslie M Shaw, Erik D Roberson, Charles F Murchison, Rachel L Henson, Tammie L S Benzinger, Quoc Bui, Folasade Agboola, Elizabeth Grant, Emily N Gremminger, Krista L Moulder, David S Geldmacher, Olivio J Clay, Ganesh Babulal, Cruchaga Carlos, David M Holtzman, Randell J Bateman, John C Morris, Suzanne E Schindler
Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals. Nature communications 15 (1) (2024)
Chengjie Xiong, Suzanne Schindler, Jingqin R Luo, John Morris, Randell J Bateman, David M Holtzman, Cruchaga Carlos, Ganesh Babulal, Rachel Henson, Tammie L S Benzinger, Quoc Bui, Folasade Agboola, Elizabeth Grant, Gremminger Emily, Krista Moulder, David Geldmacher, Olivio Clay, Erik D Roberson, Charles Murchison, David Wolk, Leslie Shaw
Baseline levels and longitudinal rates of change in plasma Aβ42/40 among self-identified Black/African American and White individuals. Research square (2024)
Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John P Budde, Patsy Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Jen Gentsch, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Daniel Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N Do, Yun Ju Sung, Guoyan Zhao, John C Morris, Krista Moulder, David M Holtzman, Randell J Bateman, Celeste M Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E Schindler, Joyce Joy Balls-Berry, Tammie L S Benzinger, Richard J Perrin, Andrea Denny, B Joy Snider, Susan L Stark, Laura Ibanez, Cruchaga Carlos
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center. Scientific data 11 (1) (2024)
Sneha Narasimhan, David M Holtzman, Liana G Apostolova, Carlos Cruchaga, Colin L Masters, John Hardy, Victor L Villemagne, Joanne Bell, Min Cho, Harald Hampel
Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway. Nature neuroscience 27 (7) (2024)
Zengjie Xia, Emily E Prescott, Agnieszka Urbanek, Hollie E Wareing, Marianne C King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A Barnes, Martyna M Matuszyk, Eleni Dimou, Eric Hidari, Yu P Zhang, Jeff Y L Lam, John S H Danial, Michael R Strickland, Hong Jiang, Peter Thornton, Damian C Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B Wharton, David M Holtzman, Tarja Malm, Rohan T Ranasinghe, David Klenerman, Suman De
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease. Nature communications 15 (1) (2024)
Jeffery M Vance, Lindsay A Farrer, Yadong Huang, Cruchaga Carlos, Bradley T Hyman, Margaret A Pericak-Vance, Alison M Goate, Michael D Greicius, Anthony J Griswold, Jonathan L Haines, Julia Tcw, Gerard D Schellenberg, Li-Huei Tsai, Joachim Herz, David M Holtzman
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Annals of neurology 95 (4) (2024)
Cruchaga Carlos, Muhammad Ali, Yuanyuan Shen, Anh Do, Lihua Wang, Daniel Western, Menghan Liu, Aleksandra Beric, John P Budde, Jen Gentsch, Suzanne E Schindler, John Morris, David M Holtzman, Maria Fernández, Agustin Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Evert Rutledge, Hamilton Se-Hwee Oh, Edward N Wilson, Yann Le Guen, Rana Khalid, Chloe Robins, David Pulford, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sung
Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease. Research square (2024)
Gillian K Carling, Li Fan, Nessa R Foxe, Kendra Norman, Pearly Ye, Man Ying Wong, Daphne Zhu, Fangmin Yu, Jielin Xu, Allan Yarahmady, Hao Chen, Yige Huang, Sadaf Amin, Emmanouil Zacharioudakis, Xiaoying Chen, David M Holtzman, Sue-Ann Mok, Evripidis Gavathiotis, Subhash C Sinha, Feixiong Cheng, Wenjie Luo, Shiaoching Gong, Li Gan
Alzheimer's disease-linked risk alleles elevate microglial cGAS-associated senescence and neurodegeneration in a tauopathy model. bioRxiv : the preprint server for biology (2024)
Chengjie Xiong, Jingqin R Luo, David A Wolk, Leslie M Shaw, Erik D Roberson, Charles F Murchison, Rachel L Henson, Tammie L S Benzinger, Quoc Bui, Folasade Agboola, Elizabeth Grant, Emily N Gremminger, Krista L Moulder, David S Geldmacher, Olivio J Clay, Ganesh Babulal, Cruchaga Carlos, David M Holtzman, Randell J Bateman, John C Morris, Suzanne E Schindler
Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals. Nature communications 15 (1) (2024)
Cruchaga Carlos, Muhammad Ali, Yuanyuan Shen, Anh Do, Lihua Wang, Daniel Western, Menghan Liu, Aleksandra Beric, John P Budde, Jen Gentsch, Suzanne E Schindler, John Morris, David M Holtzman, Maria Fernández, Agustin Ruiz, Ignacio Alvarez, Miquel Aguilar, Pau Pastor, Jarod Evert Rutledge, Hamilton Se-Hwee Oh, Edward N Wilson, Yann Le Guen, Rana Khalid, Chloe Robins, David Pulford, Laura Ibanez, Tony Wyss-Coray, Yun Ju Sung
Multi-cohort cerebrospinal fluid proteomics identifies robust molecular signatures for asymptomatic and symptomatic Alzheimer's disease. Research square (2024)
Cruchaga Carlos, Joseph Bradley, Daniel Western, Ciyang Wang, Eder Lucio Da Fonseca, Achal Neupane, Jiji T Kurup, NIcholas Ray, Melissa Jean-Francois, Priyanka Gorijala, Kristy Bergmann, John P Budde, Eden Martin, Margaret A Pericak-Vance, Michael Cuccaro, Brian Kunkle, John Morris, David M Holtzman, Richard J Perrin, Adam C Naj, Jonathan L Haines, Gerard Schellenberg, Victoria Fernandez, Christiane Reitz, Gary Beecham, null null, null null
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways. Research square (2024)
Chengjie Xiong, Suzanne Schindler, Jingqin R Luo, John Morris, Randell J Bateman, David M Holtzman, Cruchaga Carlos, Ganesh Babulal, Rachel Henson, Tammie L S Benzinger, Quoc Bui, Folasade Agboola, Elizabeth Grant, Emily Gremminger, Krista Moulder, David Geldmacher, Olivio Clay, Erik D Roberson, Charles Murchison, David Wolk, Leslie Shaw
Baseline levels and longitudinal rates of change in plasma Aβ42/40 among self-identified Black/African American and White individuals. Research square (2024)
Mika P Cadiz, Katelin A Gibson, Kennedi T Todd, David G Nascari, Nashali Massa, Meredith T Lilley, Kimberly C Olney, Md Mamun Al-Amin, Hong Jiang, David M Holtzman, John D Fryer
Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations. The Journal of experimental medicine 221 (2) (2024)
Mika P Cadiz, Katelin A Gibson, Kennedi T Todd, David G Nascari, Nashali Massa, Meredith T Lilley, Kimberly C Olney, Md Mamun Al-Amin, Hong Jiang, David M Holtzman, John D Fryer
Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations. The Journal of experimental medicine 221 (2) (2024)
Mika P Cadiz, Katelin A Gibson, Kennedi T Todd, David G Nascari, Nashali Massa, Meredith T Lilley, Kimberly C Olney, Md Mamun Al-Amin, Hong Jiang, David M Holtzman, John D Fryer
Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations. The Journal of experimental medicine 221 (2) (2024)
Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John P Budde, Patsy Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Jen Gentsch, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Daniel Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N Do, Yun Ju Sung, Guoyan Zhao, John C Morris, Krista Moulder, David M Holtzman, Randell J Bateman, Celeste M Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E Schindler, Joyce Joy Balls-Berry, Tammie L S Benzinger, Richard J Perrin, Andrea Denny, B Joy Snider, Susan L Stark, Laura Ibanez, Cruchaga Carlos
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center. Scientific data 11 (1) (2024)
Zhao Sun, Ji-Sun Kwon, Yudong Ren, Shawei Chen, Courtney K Walker, Xinguo Lu, Kitra Cates, Hande Karahan, Sanja Sviben, James A J Fitzpatrick, Clarissa Valdez, Henry Houlden, Celeste M Karch, Randell J Bateman, Chihiro Sato, Steven J Mennerick, Marc I Diamond, Jungsu Kim, Rudolph E Tanzi, David M Holtzman, Andrew S Yoo
Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming. Science (New York, N.Y.) 385 (6708) (2024)
Jeffery M Vance, Lindsay A Farrer, Yadong Huang, Cruchaga Carlos, Bradley T Hyman, Margaret A Pericak-Vance, Alison M Goate, Michael D Greicius, Anthony J Griswold, Jonathan L Haines, Julia Tcw, Gerard D Schellenberg, Li-Huei Tsai, Joachim Herz, David M Holtzman
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Annals of neurology (2024)
Cruchaga Carlos, Joseph Bradley, Daniel Western, Ciyang Wang, Eder Lucio Da Fonseca, Achal Neupane, Jiji T Kurup, NIcholas Ray, Melissa Jean-Francois, Priyanka Gorijala, Kristy Bergmann, John P Budde, Eden Martin, Margaret A Pericak-Vance, Michael Cuccaro, Brian Kunkle, John Morris, David M Holtzman, Richard J Perrin, Adam C Naj, Jonathan L Haines, Gerard Schellenberg, Victoria Fernandez, Christiane Reitz, Gary Beecham, Alzheimer's Disease Genetics Consortium, Charles F And Joanne Knight Alzheimer's Disease Research Ce Adrc
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways. Research square (2024)
Sneha Narasimhan, David M Holtzman, Liana G Apostolova, Carlos Cruchaga, Colin L Masters, John Hardy, Victor L Villemagne, Joanne Bell, Min Cho, Harald Hampel
Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway. Nature neuroscience (2024)
Antoine Anfray, Samantha Schaeffer, Yorito Hattori, Monica M Santisteban, Nicole Casey, Gang Wang, Michael R Strickland, Ping Zhou, David M Holtzman, Josef Anrather, Laibaik Park, Costantino Iadecola
A cell-autonomous role for border-associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury. Nature neuroscience (2024)
Francis Shue, Launia J White, Rachel D Hendrix, Jason D Ulrich, Rachel L Henson, William Knight, Yuka A Martens, Ni Wang, Bhaskar Roy, Skylar C Starling, Yingxue Ren, Chengjie Xiong, Yan W Asmann, Jeremy A Syrjanen, Maria Vassilaki, Michelle M Mielke, Jigyasha Timsina, Yun Ju Sung, Cruchaga Carlos, David M Holtzman, Guojun Bu, Ronald C Petersen, Michael G Heckman, Takahisa Kanekiyo
CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly. Science advances 10 (14) (2024)
Francis Shue, Launia J White, Rachel D Hendrix, Jason D Ulrich, Rachel L Henson, William Knight, Yuka A Martens, Ni Wang, Bhaskar Roy, Skylar C Starling, Yingxue Ren, Chengjie Xiong, Yan W Asmann, Jeremy A Syrjanen, Maria Vassilaki, Michelle M Mielke, Jigyasha Timsina, Yun Ju Sung, Cruchaga Carlos, David M Holtzman, Guojun Bu, Ronald C Petersen, Michael G Heckman, Takahisa Kanekiyo
CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly. Science advances 10 (14) (2024)
Danira Toral-Rios, Justin M Long, Jason D Ulrich, Jinsheng Yu, Michael R Strickland, Xianlin Han, David M Holtzman, Anil G Cashikar, Steven M Paul
Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of experimental medicine 221 (4) (2024)
Jin-Chao Hou, Yun Chen, Zhangying Cai, Gyu Seong Heo, Carla M Yuede, Zuoxu Wang, Kent Lin, Fareeha Saadi, Tihana Trsan, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Yiyang Zhu, Nicole D Wagner, Nolan McLaughlin, Xinyi Cynthia Kuang, Alexander D Barrow, Dian Li, Yingyue Zhou, Shoutang Wang, Susan Gilfillan, Michael L Gross, Simone Brioschi, Yongjian Liu, David M Holtzman, Marco Colonna
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model. Science translational medicine 16 (741) (2024)
Danira Toral-Rios, Justin M Long, Jason D Ulrich, Jinsheng Yu, Michael R Strickland, Xianlin Han, David M Holtzman, Anil G Cashikar, Steven M Paul
Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of experimental medicine 221 (4) (2024)
Mika P Cadiz, Katelin A Gibson, Kennedi T Todd, David G Nascari, Nashali Massa, Meredith T Lilley, Kimberly C Olney, Md Mamun Al-Amin, Hong Jiang, David M Holtzman, John D Fryer
Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations. The Journal of experimental medicine 221 (2) (2024)
Sneha Narasimhan, David M Holtzman, Liana G Apostolova, Carlos Cruchaga, Colin L Masters, John Hardy, Victor L Villemagne, Joanne Bell, Min Cho, Harald Hampel
Apolipoprotein E in Alzheimer's disease trajectories and the next-generation clinical care pathway. Nature neuroscience 27 (7) (2024)
Jin-Chao Hou, Yun Chen, Zhangying Cai, Gyu Seong Heo, Carla M Yuede, Zuoxu Wang, Kent Lin, Fareeha Saadi, Tihana Trsan, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Yiyang Zhu, Nicole D Wagner, Nolan McLaughlin, Xinyi Cynthia Kuang, Alexander D Barrow, Dian Li, Yingyue Zhou, Shoutang Wang, Susan Gilfillan, Michael L Gross, Simone Brioschi, Yongjian Liu, David M Holtzman, Marco Colonna
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model. Science translational medicine 16 (741) (2024)
Francis Shue, Launia J White, Rachel D Hendrix, Jason D Ulrich, Rachel L Henson, William Knight, Yuka A Martens, Ni Wang, Bhaskar Roy, Skylar C Starling, Yingxue Ren, Chengjie Xiong, Yan W Asmann, Jeremy A Syrjanen, Maria Vassilaki, Michelle M Mielke, Jigyasha Timsina, Yun Ju Sung, Cruchaga Carlos, David M Holtzman, Guojun Bu, Ronald C Petersen, Michael G Heckman, Takahisa Kanekiyo
CSF biomarkers of immune activation and Alzheimer's disease for predicting cognitive impairment risk in the elderly. Science advances 10 (14) (2024)
Cruchaga Carlos, Joseph Bradley, Daniel Western, Ciyang Wang, Eder Lucio Da Fonseca, Achal Neupane, Jiji T Kurup, NIcholas Ray, Melissa Jean-Francois, Priyanka Gorijala, Kristy Bergmann, John P Budde, Eden Martin, Margaret A Pericak-Vance, Michael Cuccaro, Brian Kunkle, John Morris, David M Holtzman, Richard J Perrin, Adam C Naj, Jonathan L Haines, Gerard Schellenberg, Victoria Fernandez, Christiane Reitz, Gary Beecham, null null, null null
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways. Research square (2024)
Zengjie Xia, Emily E Prescott, Agnieszka Urbanek, Hollie E Wareing, Marianne C King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A Barnes, Martyna M Matuszyk, Eleni Dimou, Eric Hidari, Yu P Zhang, Jeff Y L Lam, John S H Danial, Michael R Strickland, Hong Jiang, Peter Thornton, Damian C Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B Wharton, David M Holtzman, Tarja Malm, Rohan T Ranasinghe, David Klenerman, Suman De
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease. Nature communications 15 (1) (2024)
Zhao Sun, Ji-Sun Kwon, Yudong Ren, Shawei Chen, Courtney K Walker, Xinguo Lu, Kitra Cates, Hande Karahan, Sanja Sviben, James A J Fitzpatrick, Clarissa Valdez, Henry Houlden, Celeste M Karch, Randell J Bateman, Chihiro Sato, Steven J Mennerick, Marc I Diamond, Jungsu Kim, Rudolph E Tanzi, David M Holtzman, Andrew S Yoo
Modeling late-onset Alzheimer's disease neuropathology via direct neuronal reprogramming. Science (New York, N.Y.) 385 (6708) (2024)
Jin-Chao Hou, Yun Chen, Zhangying Cai, Gyu Seong Heo, Carla M Yuede, Zuoxu Wang, Kent Lin, Fareeha Saadi, Tihana Trsan, Aivi T Nguyen, Eleni Constantopoulos, Rachel A Larsen, Yiyang Zhu, Nicole D Wagner, Nolan McLaughlin, Xinyi Cynthia Kuang, Alexander D Barrow, Dian Li, Yingyue Zhou, Shoutang Wang, Susan Gilfillan, Michael L Gross, Simone Brioschi, Yongjian Liu, David M Holtzman, Marco Colonna
Antibody-mediated targeting of human microglial leukocyte Ig-like receptor B4 attenuates amyloid pathology in a mouse model. Science translational medicine 16 (741) (2024)
Zengjie Xia, Emily E Prescott, Agnieszka Urbanek, Hollie E Wareing, Marianne C King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A Barnes, Martyna M Matuszyk, Eleni Dimou, Eric Hidari, Yu P Zhang, Jeff Y L Lam, John S H Danial, Michael R Strickland, Hong Jiang, Peter Thornton, Damian C Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B Wharton, David M Holtzman, Tarja Malm, Rohan T Ranasinghe, David Klenerman, Suman De
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease. Nature communications 15 (1) (2024)
Danira Toral-Rios, Justin M Long, Jason D Ulrich, Jinsheng Yu, Michael R Strickland, Xianlin Han, David M Holtzman, Anil G Cashikar, Steven M Paul
Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of experimental medicine 221 (4) (2024)
Mika P Cadiz, Katelin A Gibson, Kennedi T Todd, David G Nascari, Nashali Massa, Meredith T Lilley, Kimberly C Olney, Md Mamun Al-Amin, Hong Jiang, David M Holtzman, John D Fryer
Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations. The Journal of experimental medicine 221 (2) (2024)
Zengjie Xia, Emily E Prescott, Agnieszka Urbanek, Hollie E Wareing, Marianne C King, Anna Olerinyova, Helen Dakin, Tom Leah, Katy A Barnes, Martyna M Matuszyk, Eleni Dimou, Eric Hidari, Yu P Zhang, Jeff Y L Lam, John S H Danial, Michael R Strickland, Hong Jiang, Peter Thornton, Damian C Crowther, Sohvi Ohtonen, Mireia Gómez-Budia, Simon M Bell, Laura Ferraiuolo, Heather Mortiboys, Adrian Higginbottom, Stephen B Wharton, David M Holtzman, Tarja Malm, Rohan T Ranasinghe, David Klenerman, Suman De
Co-aggregation with Apolipoprotein E modulates the function of Amyloid-β in Alzheimer's disease. Nature communications 15 (1) (2024)
Danira Toral-Rios, Justin M Long, Jason D Ulrich, Jinsheng Yu, Michael R Strickland, Xianlin Han, David M Holtzman, Anil G Cashikar, Steven M Paul
Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of experimental medicine 221 (4) (2024)
Maria Victoria Fernandez, Menghan Liu, Aleksandra Beric, Matt Johnson, Arda Cetin, Maulik Patel, John P Budde, Patsy Kohlfeld, Kristy Bergmann, Joseph Lowery, Allison Flynn, William Brock, Brenda Sanchez Montejo, Jen Gentsch, Nicholas Sykora, Joanne Norton, Jen Gentsch, Olga Valdez, Priyanka Gorijala, Jessie Sanford, Yichen Sun, Ciyang Wang, Daniel Western, Jigyasha Timsina, Tassia Mangetti Goncalves, Anh N Do, Yun Ju Sung, Guoyan Zhao, John C Morris, Krista Moulder, David M Holtzman, Randell J Bateman, Celeste M Karch, Jason Hassenstab, Chengjie Xiong, Suzanne E Schindler, Joyce Joy Balls-Berry, Tammie L S Benzinger, Richard J Perrin, Andrea Denny, B Joy Snider, Susan L Stark, Laura Ibanez, Cruchaga Carlos
Genetic and multi-omic resources for Alzheimer disease and related dementia from the Knight Alzheimer Disease Research Center. Scientific data 11 (1) (2024)
Jeffery M Vance, Lindsay A Farrer, Yadong Huang, Cruchaga Carlos, Bradley T Hyman, Margaret A Pericak-Vance, Alison M Goate, Michael D Greicius, Anthony J Griswold, Jonathan L Haines, Julia Tcw, Gerard D Schellenberg, Li-Huei Tsai, Joachim Herz, David M Holtzman
Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Annals of neurology 95 (4) (2024)
Danira Toral-Rios, Justin M Long, Jason D Ulrich, Jinsheng Yu, Michael R Strickland, Xianlin Han, David M Holtzman, Anil G Cashikar, Steven M Paul
Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of experimental medicine 221 (4) (2024)
Danira Toral-Rios, Justin M Long, Jason D Ulrich, Jinsheng Yu, Michael R Strickland, Xianlin Han, David M Holtzman, Anil G Cashikar, Steven M Paul
Cholesterol 25-hydroxylase mediates neuroinflammation and neurodegeneration in a mouse model of tauopathy. The Journal of experimental medicine 221 (4) (2024)
Mika P Cadiz, Katelin A Gibson, Kennedi T Todd, David G Nascari, Nashali Massa, Meredith T Lilley, Kimberly C Olney, Md Mamun Al-Amin, Hong Jiang, David M Holtzman, John D Fryer
Aducanumab anti-amyloid immunotherapy induces sustained microglial and immune alterations. The Journal of experimental medicine 221 (2) (2024)
Chengjie Xiong, Jingqin R Luo, David A Wolk, Leslie M Shaw, Erik D Roberson, Charles F Murchison, Rachel L Henson, Tammie L S Benzinger, Quoc Bui, Folasade Agboola, Elizabeth Grant, Emily N Gremminger, Krista L Moulder, David S Geldmacher, Olivio J Clay, Ganesh Babulal, Cruchaga Carlos, David M Holtzman, Randell J Bateman, John C Morris, Suzanne E Schindler
Baseline levels and longitudinal changes in plasma Aβ42/40 among Black and white individuals. Nature communications 15 (1) (2024)
Cruchaga Carlos, Joseph Bradley, Daniel Western, Ciyang Wang, Eder Lucio Da Fonseca, Achal Neupane, Jiji T Kurup, NIcholas Ray, Melissa Jean-Francois, Priyanka Gorijala, Kristy Bergmann, John P Budde, Eden Martin, Margaret A Pericak-Vance, Michael Cuccaro, Brian Kunkle, John Morris, David M Holtzman, Richard J Perrin, Adam C Naj, Jonathan L Haines, Gerard Schellenberg, Victoria Fernandez, Christiane Reitz, Gary Beecham, Alzheimer's Disease Genetics Consortium, Charles F And Joanne Knight Alzheimer's Disease Research Ce Adrc
Novel early-onset Alzheimer-associated genes influence risk through dysregulation of glutamate, immune activation, and intracell signaling pathways. Research square (2024)
Dong-Oh Seo, David O'Donnell, Nimansha Jain, Jason D Ulrich, Jasmin Herz, Yuhao Li, Mackenzie E Lemieux, Jiye Cheng, Hao Hu, Javier Remolina Serrano, Xin Bao, Emily Franke, Maria Karlsson, Martin Meier, Su Deng, Chandani Desai, Hemraj B Dodiya, Janaki Lelwala-Guruge, Scott A Handley, Jonathan Kipnis, Sangram S Sisodia, Jeffrey I Gordon, David M Holtzman
ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science (New York, N.Y.) 379 (6628) (2023)
Xiaoying Chen, Maria Firulyova, Melissa Manis, Jasmin Herz, Igor Smirnov, Ekaterina Aladyeva, Chanung Wang, Xin Bao, Mary Beth Finn, Hao Hu, Irina Shchukina, Min Woo Kim, Carla M Yuede, Jonathan Kipnis, Maxim N Artyomov, Jason D Ulrich, David M Holtzman
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature (2023)
Rui Sun, Rowland H Han, Colin McCornack, Saad M Khan, G Travis Tabor, Yun Chen, Jinchao Hou, Haowu Jiang, Kathleen M Schoch, Diane D Mao, Ryan Cleary, Alicia Yang, Qin Liu, Jingqin R Luo, Allegra A Petti, Timothy M Miller, Jason D Ulrich, David M Holtzman, Albert H Kim
TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma. Science advances 9 (19) (2023)
Rui Sun, Rowland H Han, Colin McCornack, Saad M Khan, G Travis Tabor, Yun Chen, Jinchao Hou, Haowu Jiang, Kathleen M Schoch, Diane D Mao, Ryan Cleary, Alicia Yang, Qin Liu, Jingqin R Luo, Allegra A Petti, Timothy M Miller, Jason D Ulrich, David M Holtzman, Albert H Kim
TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma. Science advances 9 (19) (2023)
Samira Parhizkar, Grace Gent, Yun Chen, Nicholas Rensing, Maud Gratuze, Gregory Strout, Sanja Sviben, Eric Tycksen, Qiang Zhang, Petra Erdmann Gilmore, Robert W Sprung, Jim Malone, Wei Chen, Javier Remolina Serrano, Xin Bao, Choonghee Lee, Chanung Wang, Eric C Landsness, James A J Fitzpatrick, Michael Wong, Robert R Townsend, Marco Colonna, Robert E Schmidt, David M Holtzman
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2 -dependent manner in mice. Science translational medicine 15 (693) (2023)
Monica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Xin Bao, Megan E Bosch, Choonghee Lee, Hong Jiang, Javier Remolina Serrano, Ernesto R Gonzales, Michal Kipnis, David M Holtzman
Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy. Molecular neurodegeneration 18 (1) (2023)
Samira Parhizkar, Grace Gent, Yun Chen, Nicholas Rensing, Maud Gratuze, Gregory Strout, Sanja Sviben, Eric Tycksen, Qiang Zhang, Petra Erdmann Gilmore, Robert W Sprung, Jim Malone, Wei Chen, Javier Remolina Serrano, Xin Bao, Choonghee Lee, Chanung Wang, Eric C Landsness, James A J Fitzpatrick, Michael Wong, Robert R Townsend, Marco Colonna, Robert E Schmidt, David M Holtzman
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2 -dependent manner in mice. Science translational medicine 15 (693) (2023)
Costantino Iadecola, Antoine Anfray, Samantha Schaeffer, Yorito Hattori, Monica M Santisteban, Nicole Casey, Gang Wang, Michael R Strickland, Ping Zhou, David M Holtzman, Josef Anrather, Laibaik Park
Cell autonomous role of border associated macrophages in ApoE4 neurovascular dysfunction and susceptibility to white matter injury. Research square (2023)
Dong-Oh Seo, David O'Donnell, Nimansha Jain, Jason D Ulrich, Jasmin Herz, Yuhao Li, Mackenzie E Lemieux, Jiye Cheng, Hao Hu, Javier Remolina Serrano, Xin Bao, Emily Franke, Maria Karlsson, Martin Meier, Su Deng, Chandani Desai, Hemraj B Dodiya, Janaki Lelwala-Guruge, Scott A Handley, Jonathan Kipnis, Sangram S Sisodia, Jeffrey I Gordon, David M Holtzman
ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science (New York, N.Y.) 379 (6628) (2023)
Wade K Self, David M Holtzman
Emerging diagnostics and therapeutics for Alzheimer disease. Nature medicine (2023)
Xiaoying Chen, Maria Firulyova, Melissa Manis, Jasmin Herz, Igor Smirnov, Ekaterina Aladyeva, Chanung Wang, Xin Bao, Mary Beth Finn, Hao Hu, Irina Shchukina, Min Woo Kim, Carla M Yuede, Jonathan Kipnis, Maxim N Artyomov, Jason D Ulrich, David M Holtzman
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature 615 (7953) (2023)
Kanta Horie, Gemma Salvadó, Nicolas R Barthélemy, Shorena Janelidze, Yan Li, Yingxin He, Benjamin Saef, Charles D Chen, Hong Jiang, Olof Strandberg, Alexa Pichet Binette, Sebastian Palmqvist, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Brian A Gordon, Tammie L S Benzinger, David M Holtzman, John C Morris, Niklas Mattsson-Carlgren, Erik Stomrud, Rik Ossenkoppele, Suzanne E Schindler, Oskar Hansson, Randell J Bateman
CSF MTBR-tau243 is a specific biomarker of tau tangle pathology in Alzheimer's disease. Nature medicine (2023)
Samira Parhizkar, Grace Gent, Yun Chen, Nicholas Rensing, Maud Gratuze, Gregory Strout, Sanja Sviben, Eric Tycksen, Qiang Zhang, Petra Erdmann Gilmore, Robert W Sprung, Jim Malone, Wei Chen, Javier Remolina Serrano, Xin Bao, Choonghee Lee, Chanung Wang, Eric C Landsness, James A J Fitzpatrick, Michael Wong, Robert R Townsend, Marco Colonna, Robert E Schmidt, David M Holtzman
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2 -dependent manner in mice. Science translational medicine 15 (693) (2023)
Dong-Oh Seo, David O'Donnell, Nimansha Jain, Jason D Ulrich, Jasmin Herz, Yuhao Li, Mackenzie E Lemieux, Jiye Cheng, Hao Hu, Javier Remolina Serrano, Xin Bao, Emily Franke, Maria Karlsson, Martin Meier, Su Deng, Chandani Desai, Hemraj B Dodiya, Janaki Lelwala-Guruge, Scott A Handley, Jonathan Kipnis, Sangram S Sisodia, Jeffrey I Gordon, David M Holtzman
ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science (New York, N.Y.) 379 (6628) (2023)
Monica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Xin Bao, Megan E Bosch, Choonghee Lee, Hong Jiang, Javier Remolina Serrano, Ernesto R Gonzales, Michal Kipnis, David M Holtzman
Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy. Molecular neurodegeneration 18 (1) (2023)
Antoine Drieu, Siling Du, Michal Kipnis, Megan E Bosch, Jasmin Herz, Choonghee Lee, Hong Jiang, Melissa Manis, Jason D Ulrich, Jonathan Kipnis, David M Holtzman, Maud Gratuze
Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration. Life science alliance 6 (11) (2023)
Gemma Salvadó, Kanta Horie, Nicolas R Barthélemy, Jacob W Vogel, Alexa Pichet Binette, Charles D Chen, Andrew J Aschenbrenner, Brian A Gordon, Tammie L S Benzinger, David M Holtzman, John C Morris, Sebastian Palmqvist, Erik Stomrud, Shorena Janelidze, Rik Ossenkoppele, Suzanne E Schindler, Randell J Bateman, Oskar Hansson
Novel CSF tau biomarkers can be used for disease staging of sporadic Alzheimer's disease. medRxiv : the preprint server for health sciences (2023)
Dong-Oh Seo, David O'Donnell, Nimansha Jain, Jason D Ulrich, Jasmin Herz, Yuhao Li, Mackenzie E Lemieux, Jiye Cheng, Hao Hu, Javier Remolina Serrano, Xin Bao, Emily Franke, Maria Karlsson, Martin Meier, Su Deng, Chandani Desai, Hemraj B Dodiya, Janaki Lelwala-Guruge, Scott A Handley, Jonathan Kipnis, Sangram S Sisodia, Jeffrey I Gordon, David M Holtzman
ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science (New York, N.Y.) 379 (6628) (2023)
Xiaoying Chen, Maria Firulyova, Melissa Manis, Jasmin Herz, Igor Smirnov, Ekaterina Aladyeva, Chanung Wang, Xin Bao, Mary Beth Finn, Hao Hu, Irina Shchukina, Min Woo Kim, Carla M Yuede, Jonathan Kipnis, Maxim N Artyomov, Jason D Ulrich, David M Holtzman
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature 615 (7953) (2023)
Dong-Oh Seo, David O'Donnell, Nimansha Jain, Jason D Ulrich, Jasmin Herz, Yuhao Li, Mackenzie E Lemieux, Jiye Cheng, Hao Hu, Javier Remolina Serrano, Xin Bao, Emily Franke, Maria Karlsson, Martin Meier, Su Deng, Chandani Desai, Hemraj B Dodiya, Janaki Lelwala-Guruge, Scott A Handley, Jonathan Kipnis, Sangram S Sisodia, Jeffrey I Gordon, David M Holtzman
ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science (New York, N.Y.) 379 (6628) (2023)
Dong-Oh Seo, David O'Donnell, Nimansha Jain, Jason D Ulrich, Jasmin Herz, Yuhao Li, Mackenzie E Lemieux, Jiye Cheng, Hao Hu, Javier Remolina Serrano, Xin Bao, Emily Franke, Maria Karlsson, Martin Meier, Su Deng, Chandani Desai, Hemraj B Dodiya, Janaki Lelwala-Guruge, Scott A Handley, Jonathan Kipnis, Sangram S Sisodia, Jeffrey I Gordon, David M Holtzman
ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science (New York, N.Y.) 379 (6628) (2023)
Dong-Oh Seo, David O'Donnell, Nimansha Jain, Jason D Ulrich, Jasmin Herz, Yuhao Li, Mackenzie E Lemieux, Jiye Cheng, Hao Hu, Javier Remolina Serrano, Xin Bao, Emily Franke, Maria Karlsson, Martin Meier, Su Deng, Chandani Desai, Hemraj B Dodiya, Janaki Lelwala-Guruge, Scott A Handley, Jonathan Kipnis, Sangram S Sisodia, Jeffrey I Gordon, David M Holtzman
ApoE isoform- and microbiota-dependent progression of neurodegeneration in a mouse model of tauopathy. Science (New York, N.Y.) 379 (6628) (2023)
Ilana Fogelman, Tim West, Joel B Braunstein, Philip B Verghese, Kristopher M Kirmess, Matthew R Meyer, John H Contois, Eli Shobin, Kyle L Ferber, Jake Gagnon, Carrie E Rubel, Danielle Graham, Randall J Bateman, David M Holtzman, Shuguang Huang, Joanne Yu, Sha Yang, Kevin E Yarasheski
Independent study demonstrates amyloid probability score accurately indicates amyloid pathology. Annals of clinical and translational neurology (2023)
Rui Sun, Rowland H Han, Colin McCornack, Saad M Khan, G Travis Tabor, Yun Chen, Jinchao Hou, Haowu Jiang, Kathleen M Schoch, Diane D Mao, Ryan Cleary, Alicia Yang, Qin Liu, Jingqin R Luo, Allegra A Petti, Timothy M Miller, Jason D Ulrich, David M Holtzman, Albert H Kim
TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma. Science advances 9 (19) (2023)
G Travis Tabor, David M Holtzman
Current status of amyloid-targeting immunotherapies for Alzheimer's disease. Science translational medicine 15 (721) (2023)
Monica Xiong, Chao Wang, Maud Gratuze, Fareeha Saadi, Xin Bao, Megan E Bosch, Choonghee Lee, Hong Jiang, Javier Remolina Serrano, Ernesto R Gonzales, Michal Kipnis, David M Holtzman
Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy. Molecular neurodegeneration 18 (1) (2023)
Xiaoying Chen, Maria Firulyova, Melissa Manis, Jasmin Herz, Igor Smirnov, Ekaterina Aladyeva, Chanung Wang, Xin Bao, Mary Beth Finn, Hao Hu, Irina Shchukina, Min Woo Kim, Carla M Yuede, Jonathan Kipnis, Maxim N Artyomov, Jason D Ulrich, David M Holtzman
Microglia-mediated T cell infiltration drives neurodegeneration in tauopathy. Nature (2023)
Samira Parhizkar, Grace Gent, Yun Chen, Nicholas Rensing, Maud Gratuze, Gregory Strout, Sanja Sviben, Eric Tycksen, Qiang Zhang, Petra Erdmann Gilmore, Robert W Sprung, Jim Malone, Wei Chen, Javier Remolina Serrano, Xin Bao, Choonghee Lee, Chanung Wang, Eric C Landsness, James A J Fitzpatrick, Michael Wong, Robert R Townsend, Marco Colonna, Robert E Schmidt, David M Holtzman
Sleep deprivation exacerbates microglial reactivity and Aβ deposition in a TREM2 -dependent manner in mice. Science translational medicine 15 (693) (2023)
Aura L Ferreiro, JooHee Choi, Jian Ryou, Erin P Newcomer, Regina Thompson, Rebecca M Bollinger, Carla Hall-Moore, I Malick Ndao, Laurie Sax, Tammie L S Benzinger, Susan L Stark, David M Holtzman, Anne M Fagan, Suzanne E Schindler, Cruchaga Carlos, Omar H Butt, John C Morris, Phillip I Tarr, Beau M Ances, Gautam Dantas
Gut microbiome composition may be an indicator of preclinical Alzheimer's disease. Science translational medicine 15 (700) (2023)
Rui Sun, Rowland H Han, Colin McCornack, Saad M Khan, G Travis Tabor, Yun Chen, Jinchao Hou, Haowu Jiang, Kathleen M Schoch, Diane D Mao, Ryan Cleary, Alicia Yang, Qin Liu, Jingqin R Luo, Allegra A Petti, Timothy M Miller, Jason D Ulrich, David M Holtzman, Albert H Kim
TREM2 inhibition triggers antitumor cell activity of myeloid cells in glioblastoma. Science advances 9 (19) (2023)
Nimansha Jain, Caroline A Lewis, Jason D Ulrich, David M Holtzman
Chronic TREM2 activation exacerbates Aβ-associated tau seeding and spreading. The Journal of experimental medicine 220 (1) (2022)
Carolyn N Mann, Shamulailatpam Shreedarshanee Devi, Corey T Kersting, Amber V Bleem, Celeste M Karch, David M Holtzman, Gilbert Gallardo
Astrocytic α2-Na + /K + ATPase inhibition suppresses astrocyte reactivity and reduces neurodegeneration in a tauopathy mouse model. Science translational medicine 14 (632) (2022)
Tarin M Bigley, Monica Xiong, Muhammad Ali, Yun Chen, Chao Wang, Javier Remolina Serrano, Abdallah Eteleeb, Oscar Harari, Liping Yang, Swapneel J Patel, Carlos Cruchaga, Wayne M Yokoyama, David M Holtzman
Murine roseolovirus does not accelerate amyloid-β pathology and human roseoloviruses are not over-represented in Alzheimer disease brains. Molecular neurodegeneration 17 (1) (2022)
Thomas E Mahan, Chao Wang, Xin Bao, Ankit Choudhury, Jason D Ulrich, David M Holtzman
Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis. Molecular neurodegeneration 17 (1) (2022)
Aylin Dincer, Charles D Chen, Nicole S McKay, Lauren N Koenig, Austin McCullough, Shaney Flores, Sarah J Keefe, Stephanie A Schultz, Rebecca L Feldman, Nelly Joseph-Mathurin, Russ C Hornbeck, Cruchaga Carlos, Suzanne E Schindler, David M Holtzman, John C Morris, Anne M Fagan, Tammie L S Benzinger, Brian A Gordon
APOE ε4 genotype, amyloid-β, and sex interact to predict tau in regions of high APOE mRNA expression. Science translational medicine 14 (671) (2022)
Maud Gratuze, Hong Jiang, Chanung Wang, Monica Xiong, Xin Bao, David M Holtzman
APOE Antibody Inhibits Aβ-Associated Tau Seeding and Spreading in a Mouse Model. Annals of neurology 91 (6) (2022)
Albert A Davis, Casey E Inman, Zachary M Wargel, Umber Dube, Brittany M Freeberg, Alexander Galluppi, Jessica N Haines, Dhruva D Dhavale, Rebecca L Miller, Fahim A Choudhury, Patrick M Sullivan, Cruchaga Carlos, Joel S Perlmutter, Jason D Ulrich, Bruno A Benitez, Paul T Kotzbauer, David M Holtzman
APOE genotype regulates pathology and disease progression in synucleinopathy. Science translational medicine 12 (529) (2021)
Maud Gratuze, Yun Chen, Samira Parhizkar, Nimansha Jain, Michael R Strickland, Javier Remolina Serrano, Marco Colonna, Jason D Ulrich, David M Holtzman
Activated microglia mitigate Aβ-associated tau seeding and spreading. The Journal of experimental medicine 218 (8) (2021)
Alexandra Litvinchuk, Tien-Phat V Huynh, Yang Shi, Rosemary J Jackson, Mary B Finn, Melissa Manis, Caroline M Francis, Ainsley C Tran, Patrick M Sullivan, Jason D Ulrich, Bradley T Hyman, Tracy Cole, David M Holtzman
Apolipoprotein E4 Reduction with Antisense Oligonucleotides Decreases Neurodegeneration in a Tauopathy Model. Annals of neurology 89 (5) (2021)
Suzanne E Schindler, Yan Li, Virginia D Buckles, Brian A Gordon, Tammie L S Benzinger, Guoqiao Wang, Dean Coble, William E Klunk, Anne M Fagan, David M Holtzman, Randell J Bateman, John C Morris, Chengjie Xiong
Predicting Symptom Onset in Sporadic Alzheimer Disease With Amyloid PET. Neurology 97 (18) (2021)
Monica Xiong, Hong Jiang, Javier Remolina Serrano, Ernesto R Gonzales, Chao Wang, Maud Gratuze, Rosa Hoyle, Nga Bien-Ly, Adam P Silverman, Patrick M Sullivan, Ryan J Watts, Jason D Ulrich, Gregory J Zipfel, David M Holtzman
APOE immunotherapy reduces cerebral amyloid angiopathy and amyloid plaques while improving cerebrovascular function. Science translational medicine 13 (581) (2021)
Hao Wang, Joshua A Kulas, Chao Wang, David M Holtzman, Heather A Ferris, Scott B Hansen
Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol. Proceedings of the National Academy of Sciences of the United States of America 118 (33) (2021)
Brendan P Lucey, Austin McCullough, Eric C Landsness, Cristina D Toedebusch, Jennifer S McLeland, Aiad M Zaza, Anne M Fagan, Lena McCue, Chengjie Xiong, John C Morris, Tammie L S Benzinger, David M Holtzman
Reduced non-rapid eye movement sleep is associated with tau pathology in early Alzheimer's disease. Science translational medicine 11 (474) (2020)
Clifford R Jack, David M Holtzman, Reisa A Sperling
Dementia is not synonymous with Alzheimer's disease. Science translational medicine 11 (522) (2020)
Jerrah K Holth, Sarah K Fritschi, Chanung Wang, Nigel Paul Pedersen, John R Cirrito, Thomas E Mahan, Mary Beth Finn, Melissa Manis, Joel C Geerling, Patrick M Fuller, Brendan P Lucey, David M Holtzman
The sleep-wake cycle regulates brain interstitial fluid tau in mice and CSF tau in humans. Science (New York, N.Y.) 363 (6429) (2019)
Tien-Phat V Huynh, Chao Wang, Ainsley C Tran, G Travis Tabor, Thomas E Mahan, Caroline M Francis, Mary Beth Finn, Rebecca Spellman, Melissa Manis, Rudolph E Tanzi, Jason D Ulrich, David M Holtzman
Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model. Molecular neurodegeneration 14 (1) (2019)
Tirth K Patel, LeMoyne Habimana-Griffin, Xuefeng Gao, Baogang Xu, Samuel Achilefu, Kari Alitalo, Celia A McKee, Patrick W Sheehan, Erik S Musiek, Chengjie Xiong, Dean Coble, David M Holtzman
Dural lymphatics regulate clearance of extracellular tau from the CNS. Molecular neurodegeneration 14 (1) (2019)
Cheryl E G Leyns, Maud Gratuze, Sneha Narasimhan, Nimansha Jain, Lauren J Koscal, Hong Jiang, Melissa Manis, Marco Colonna, Virginia M Y Lee, Jason D Ulrich, David M Holtzman
TREM2 function impedes tau seeding in neuritic plaques. Nature neuroscience 22 (8) (2019)
Yang Shi, Melissa Manis, Justin M Long, Kairuo Wang, Patrick M Sullivan, Javier Remolina Serrano, Rosa Hoyle, David M Holtzman
Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model. The Journal of experimental medicine 216 (11) (2019)
Christian B Lessard, Samuel L Malnik, Yingyue Zhou, Thomas B Ladd, Pedro E Cruz, Yong Ran, Thomas E Mahan, Paramita Chakrabaty, David M Holtzman, Jason D Ulrich, Marco Colonna, Griffin Golde
High-affinity interactions and signal transduction between Aβ oligomers and TREM2. EMBO molecular medicine 10 (11) (2019)

David M Holtzman.css-eqlu8i{font-size:small;padding-left:4px;} (David Holtzman)

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David M Holtzman (David Holtzman)