Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming.
Karen L LeungSmriti SanchitaCatherine T PhamBrett A DavisMariam OkhovatXiangming DingPhillip DumesicTristan R GroganKevin J WilliamsMarco MorselliFeiyang MaLucia CarboneXinmin LiMatteo PellegriniDaniel A DumesicGregorio D ChazenbalkPublished in: Clinical epigenetics (2020)
In normal-weight PCOS women, dynamic chromatin remodeling of SC abdominal ASCs during adipogenesis may enhance adipogenic gene expression as a programmed mechanism to promote greater fat storage.
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