The microRNA-7-mediated reduction in EPAC-1 contributes to vascular endothelial permeability and eNOS uncoupling in murine experimental retinopathy.

Veronica Garcia-MoralesJulian FriedrichLysanne M JornaManuel Campos-ToimilHans-Peter HammesMartina SchmidtGuido Krenning

Published in: Acta diabetologica (2017)

In retinopathy, EPAC-1 expression is decreased in a microRNA-7-mediated manner, contributing to endothelial dysfunction. Pharmacological activation of remnant EPAC-1 rescues endothelial function. Collectively, these data indicate that EPAC-1 resembles an efficacious and druggable target molecule for the amelioration of (diabetic) retinopathy.

Keyphrases

diabetic retinopathy
endothelial cells
optical coherence tomography
poor prognosis
nitric oxide synthase
electronic health record
binding protein
pi k akt
machine learning
cell proliferation
signaling pathway
data analysis