The Effect of Sodium Glucose Cotransporter-2 Inhibitors on Hemoglobin A1c Variability and Acute Kidney Injury: A Causal Mediation Analysis.

Tiansheng Wang Dongze Ji Til Stürmer Sherine IsmailShujie DongPeng ShenHongbo LinLuwen ShiXiaodong Guan Yang Xu

Published in: Pharmacoepidemiology and drug safety (2024)

Compared to DPP4i, lower AKI risk associated with SGLT2i is moderately mediated through HbA1c variability. These findings enhance our understanding of the effect of SGLT2i on AKI and underscore the importance of considering HbA1c variability in diabetes treatment and management.

Keyphrases

acute kidney injury
cardiac surgery
type diabetes
cardiovascular disease
social support
adipose tissue
depressive symptoms
combination therapy
replacement therapy
skeletal muscle
red blood cell
smoking cessation
data analysis