Urine eosinophil-derived neurotoxin: A potential marker of activity in select eosinophilic disorders.
Michelle A MakiyaPaneez KhouryFei Li KuangAlexis Dominique MataSana MahmoodAbbie BowmanDavid EspinozaNicholas KovacsThomas BrownNicole HollandLauren WetzlerJeanAnne M WareAnne-Marie DyerPraveen AkuthotaBruce S BochnerVernon M ChinchilliGerald J GleichCarol LangfordPeter A MerkelUlrich SpecksPeter F WellerMichael E WechslerCalman PrussinMichael P FayAmy D KlionPublished in: Allergy (2022)
Measurement of EGP in urine is noninvasive and unaffected by cellular lysis. Although plasma and urine EDN concentrations showed a similar pattern following benralizumab and mepolizumab treatment, the lack of correlation between AEC or prednisone dose and uEDN concentrations suggests that measurement of uEDN may provide a potential biomarker of disease activity in patients with HES and EGPA.