Effects of Quercetin on the Efficacy of Various Chemotherapeutic Drugs in Cervical Cancer Cells.

Wenbin XuShangdan XieXin ChenShuya PanHongfei QianXueqiong Zhu

Published in: Drug design, development and therapy (2021)

Quercetin and cisplatin had synergistic inhibitory effect on cervical cancer cells. Quercetin might enhance the antitumor effect of cisplatin via inhibiting proliferation, migration and invasion and elevating apoptosis through weakening MMP2, ezrin, METTL3 and P-Gp expression of cancer cells.

Keyphrases

cell cycle arrest
induced apoptosis
signaling pathway
endoplasmic reticulum stress
cell death
oxidative stress
pi k akt
poor prognosis
drug delivery
cell proliferation