Evaluation of Acquired Antithrombin Deficiency in Pediatric Patients Supported on Extracorporeal Membrane Oxygenation.
David E ProcacciniJennifer RoemDerek K NgThomas E RappoldDawoon JungJogarao V S GobburuMelania M BembeaPublished in: British journal of clinical pharmacology (2023)
There was a high prevalence of AT deficiency in pediatric ECMO patients. An AT replacement protocol based on evaluating heparin-resistance is associated with less AT administration, with similar circuit and patient outcomes. Further data are needed to identify optimal dosing strategies.
Keyphrases
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- end stage renal disease
- respiratory failure
- ejection fraction
- chronic kidney disease
- randomized controlled trial
- prognostic factors
- venous thromboembolism
- electronic health record
- mechanical ventilation
- young adults
- intensive care unit
- artificial intelligence