The course of cytokine and chemokine gene expression in clinically suspect arthralgia patients during progression to inflammatory arthritis.

Pascal Hendrik Pieter de Jong Cleo Rogier Ellis Niemantsverdriet Susan J F van den Eeden Pascal Hendrik Pieter de Jong Erik Lubberts Annemieke Geluk Annette H M van der Helm van Mil

Published in: Rheumatology (Oxford, England) (2023)

Whole-blood gene expression of assessed cytokines/chemokines/related receptors did not change significantly from CSA to IA-development. This suggests that changes in expression of these molecules may not be related to the final process of developing chronicity and may have occurred preceding CSA-onset. Changes in gene expression in CSA-patients without IA-development may provide clues for processes related to resolution.

Keyphrases

gene expression
end stage renal disease
dna methylation
chronic kidney disease
ejection fraction
newly diagnosed
poor prognosis
patient reported outcomes
long non coding rna
drug induced