TLRs and RAGE are elevated in carotid plaques from patients with moderate-to-severe obstructive sleep apnea syndrome.

Wioletta OlejarzAlicja GłuszkoAgata CyranKatarzyna Bednarek-RajewskaRobert ProczkaDavid F SmithStacey L IshmanEwa MigaczWojciech Kukwa

Published in: Sleep & breathing = Schlaf & Atmung (2020)

TLR2, TLR4, TLR9, and RAGE expression was significantly increased in carotid plaques of patients with moderate-to-severe OSA when compared with control patients with no OSA and those with mild OSA. TLR and RAGE-mediated pathways may play a significant role in OSA-dependent atherogenesis.

Keyphrases

obstructive sleep apnea
toll like receptor
positive airway pressure
inflammatory response
immune response
sleep apnea
nuclear factor
early onset
poor prognosis
high intensity