Undernutrition upregulated PD-1 and PD-L1 expression and downregulated immune signaling pathways in mice with visceral leishmaniasis. The signaling pathways and hub genes may serve as drug targets or intervention targets for the treatment of leishmaniasis patients with undernutrition.
Keyphrases
- signaling pathway
- pi k akt
- induced apoptosis
- high fat diet induced
- epithelial mesenchymal transition
- randomized controlled trial
- bioinformatics analysis
- genome wide
- early onset
- emergency department
- drug induced
- type diabetes
- combination therapy
- oxidative stress
- gene expression
- replacement therapy
- endoplasmic reticulum stress
- genome wide identification
- adverse drug