Induction of mitochondria mediated apoptosis in human ovarian cancer cells by folic acid coated tin oxide nanoparticles.
Demiana H HannaGamal R SaadPublished in: PloS one (2021)
Overall, the results suggested that an increase in cellular FA-SnO2 NPs internalization resulted in a significant induced cytotoxicity in SKOV3 cancer cells in dose-dependent mode through ROS-mediated cell apoptosis that may have occurred through mitochondrial pathway. Additionally, the results confirmed the safety of utilization FA-SnO2 NPs against living systems. So, FA-SnO2 NPs with a specific targeting moiety may be a promising therapeutic candidate for human ovarian cancer.
Keyphrases
- oxide nanoparticles
- endothelial cells
- perovskite solar cells
- reduced graphene oxide
- room temperature
- high glucose
- cell death
- induced pluripotent stem cells
- oxidative stress
- cell proliferation
- reactive oxygen species
- pluripotent stem cells
- dna damage
- diabetic rats
- gold nanoparticles
- drug induced
- ionic liquid
- endoplasmic reticulum