Low-Dose Decitabine Assists Human Umbilical Cord-Derived Mesenchymal Stem Cells in Protecting β Cells via the Modulation of the Macrophage Phenotype in Type 2 Diabetic Mice.
Jing XueYu ChengHaojie HaoJieqing GaoYaqi YinSongyan YuJunyan ZouJiejie LiuQi ZhangYi-Ming MuPublished in: Stem cells international (2020)
These data unveiled that DAC prolonged the antidiabetic effect of MSCs and promoted sustainable β-cell restoration, possibly by modulating the macrophage phenotype. Our results offer a preferable therapeutic strategy for T2D.
Keyphrases
- umbilical cord
- mesenchymal stem cells
- low dose
- induced apoptosis
- cell therapy
- endothelial cells
- adipose tissue
- cell cycle arrest
- acute myeloid leukemia
- single cell
- signaling pathway
- high dose
- bone marrow
- electronic health record
- induced pluripotent stem cells
- pluripotent stem cells
- big data
- stem cells
- oxidative stress
- cell death
- cell proliferation
- deep learning