Transcriptional phenocopies of deleterious KEAP1 mutations correlate with survival outcomes in lung cancer treated with immunotherapy.

Stefano Scalera Biagio Ricciuti Daniele Marinelli Marco Mazzotta Laura Cipriani Giulia Bon Giulia Schiavoni Irene Terrenato Alessandro Di Federico Joao M Victor Alessi Maurizio Fanciulli Ludovica Ciuffreda Francesca De Nicola Frauke Goeman Giulio Caravagna Daniele Santini Ruggero De Maria Federico Cappuzzo Gennaro Ciliberto Mariam Jamal-Hanjani Mark M Awad Nicholas McGranahan Marcello Maugeri-Saccà

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

We identified a KEAPness phenotype across evolutionary divergent tumors. KEAPness outperforms mutation-based classifiers as a biomarker of inferior survival outcomes in NSCLC patients treated with immunotherapy.

Keyphrases

small cell lung cancer
gene expression
transcription factor
advanced non small cell lung cancer
genome wide
small molecule
oxidative stress
epidermal growth factor receptor
heat stress