Nicholas McGranahan

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 58

Top Venues

Nature communications

Nature

Genome medicine

Cancer discovery

Annals of Oncology

University College London (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Annals of Oncology Jan 01 2016

United Kingdom

Associate Editor

Education History

University College London Oct 01 2011 - Nov 13 2015

United Kingdom

PHD :: Oncology

University of Bath Sep 01 2005 - Jul 01 2009

United Kingdom

BSC

Publications

Panagiotis Karras, James R M Black, Nicholas McGranahan, Jean-Christophe Marine
Decoding the interplay between genetic and non-genetic drivers of metastasis. Nature 629 (8012) (2024)
Michelle Dietzen, Haoran Zhai, Olivia Lucas, Oriol Pich, Christopher Barrington, Wei-Ting Lu, Sophia Ward, Yanping Guo, Robert Edward Hynds, Simone Zaccaria, Charles Swanton, Nicholas McGranahan, Nnennaya Kanu
Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution. Nature communications 15 (1) (2024)
Robert Edward Hynds, Ariana Huebner, David R Pearce, Mark S Hill, Ayse U Akarca, David Allan Moore, Sophia Ward, Kate H C Gowers, Takahiro Karasaki, Maise Al Bakir, Gareth A Wilson, Oriol Pich, Carlos Martínez-Ruiz, A S Md Mukarram Hossain, Simon P Pearce, Monica Sivakumar, Assma Ben Aissa, Eva Grönroos, Deepak P Chandrasekharan, Krishna K Kolluri, Rebecca Towns, Kaiwen Wang, Daniel E Cook, Leticia Bosshard-Carter, Cristina Naceur-Lombardelli, Andrew J Rowan, Selvaraju Veeriah, Kevin Litchfield, Philip A J Crosbie, Caroline Dive, Sergio A Quezada, Samuel M Janes, Mariam Jamal-Hanjani, Teresa Marafioti, null null, Nicholas McGranahan, Charles Swanton
Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models. Nature communications 15 (1) (2024)
Stefano Scalera, Biagio Ricciuti, Daniele Marinelli, Marco Mazzotta, Laura Cipriani, Giulia Bon, Giulia Schiavoni, Irene Terrenato, Alessandro Di Federico, Joao M Victor Alessi, Maurizio Fanciulli, Ludovica Ciuffreda, Francesca De Nicola, Frauke Goeman, Giulio Caravagna, Daniele Santini, Ruggero De Maria, Federico Cappuzzo, Gennaro Ciliberto, Mariam Jamal-Hanjani, Mark M Awad, Nicholas McGranahan, Marcello Maugeri-Saccà
Transcriptional phenocopies of deleterious KEAP1 mutations correlate with survival outcomes in lung cancer treated with immunotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research (2024)
Panagiotis Karras, James R M Black, Nicholas McGranahan, Jean-Christophe Marine
Decoding the interplay between genetic and non-genetic drivers of metastasis. Nature 629 (8012) (2024)
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell, Bjorn Bakker, Thomas B K Watkins, Aleksandra Markovets, Jonathan R Dry, Andrew P Brown, Jasper van der Aart, Hilda van den Bos, Diana Carolina Johanna Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H Rabinowitz, Laila Ait Hassou, Saskia Litière, D Lucas Kerr, Lisa Tan, Gavin P Kelly, David Allan Moore, Matthew J Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R M Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M Blakely, Elza C de Bruin, Floris Foijer, Karen H Vousden, Trever G Bivona, null null, Robert Edward Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature communications 15 (1) (2024)
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell, Bjorn Bakker, Thomas B K Watkins, Aleksandra Markovets, Jonathan R Dry, Andrew P Brown, Jasper van der Aart, Hilda van den Bos, Diana Carolina Johanna Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H Rabinowitz, Laila Ait Hassou, Saskia Litière, D Lucas Kerr, Lisa Tan, Gavin P Kelly, David Allan Moore, Matthew J Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R M Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M Blakely, Elza C de Bruin, Floris Foijer, Karen H Vousden, Trever G Bivona, null null, Robert Edward Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature communications 15 (1) (2024)
Katey S S Enfield, Emma C Colliver, Claudia S Y Lee, Alastair Magness, David Allan Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L Nye, Mary Green, Krijn K Dijkstra, Masako Shimato, Ayse U Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, null null, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer discovery 14 (6) (2024)
Katey S S Enfield, Emma C Colliver, Claudia S Y Lee, Alastair Magness, David Allan Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L Nye, Mary Green, Krijn K Dijkstra, Masako Shimato, Ayse U Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, null null, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer discovery 14 (6) (2024)
Alexander M Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L Lim, Takahiro Karasaki, Sophia Ward, Selvaraju Veeriah, Emma C Colliver, Ariana Huebner, Abigail Bunkum, Mark S Hill, Kristiana Grigoriadis, David Allan Moore, James R M Black, Wing Kin Liu, Kerstin Thol, Oriol Pich, Thomas B K Watkins, Cristina Naceur-Lombardelli, Daniel E Cook, Roberto Salgado, Gareth A Wilson, Chris Bailey, Mihaela Angelova, Robert Bentham, Carlos Martínez-Ruiz, Christopher Abbosh, Andrew G Nicholson, John P C Le Quesne, Dhruva Biswas, Rachel Rosenthal, Clare Puttick, Sonya Hessey, Claudia S Y Lee, Paulina Prymas, Antonia Toncheva, Jon Smith, Wei Xing, Jérôme Nicod, Gillian Price, Keith M Kerr, Babu Naidu, Gary M Middleton, Kevin G Blyth, Dean A Fennell, Martin D Forster, Siow Ming Lee, Mary Falzon, Madeleine Hewish, Michael J Shackcloth, Eric Lim, Sarah Benafif, Peter Russell, Ekaterini Boleti, Matthew G Krebs, Jason F Lester, Dionysis Papadatos-Pastos, Tanya Ahmad, Ricky M Thakrar, David Lawrence, Neal Navani, Sam M Janes, Caroline Dive, Fiona H Blackhall, Yvonne Summers, Judith Cave, Teresa Marafioti, Javier Herrero, Sergio A Quezada, Karl S Peggs, Roland F Schwarz, Peter Van Loo, Daniël M Miedema, Nicolai Juul Birkbak, Crispin T Hiley, Allan Hackshaw, Simone Zaccaria, null null, Mariam Jamal-Hanjani, Nicholas McGranahan, Charles Swanton
Author Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature (2024)
Michelle Dietzen, Haoran Zhai, Olivia Lucas, Oriol Pich, Christopher Barrington, Wei-Ting Lu, Sophia Ward, Yanping Guo, Robert Edward Hynds, Simone Zaccaria, Charles Swanton, Nicholas McGranahan, Nnennaya Kanu
Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution. Nature communications 15 (1) (2024)
Katey S S Enfield, Emma C Colliver, Claudia S Y Lee, Alastair Magness, David Allan Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L Nye, Mary Green, Krijn K Dijkstra, Masako Shimato, Ayse U Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, null null, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer discovery 14 (6) (2024)
Michelle Dietzen, Haoran Zhai, Olivia Lucas, Oriol Pich, Christopher Barrington, Wei-Ting Lu, Sophia Ward, Yanping Guo, Robert Edward Hynds, Simone Zaccaria, Charles Swanton, Nicholas McGranahan, Nnennaya Kanu
Replication timing alterations are associated with mutation acquisition during breast and lung cancer evolution. Nature communications 15 (1) (2024)
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell, Bjorn Bakker, Thomas B K Watkins, Aleksandra Markovets, Jonathan R Dry, Andrew P Brown, Jasper van der Aart, Hilda van den Bos, Diana Carolina Johanna Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H Rabinowitz, Laila Ait Hassou, Saskia Litière, D Lucas Kerr, Lisa Tan, Gavin P Kelly, David Allan Moore, Matthew J Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R M Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M Blakely, Elza C de Bruin, Floris Foijer, Karen H Vousden, Trever G Bivona, null null, Robert Edward Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature communications 15 (1) (2024)
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell, Bjorn Bakker, Thomas B K Watkins, Aleksandra Markovets, Jonathan R Dry, Andrew P Brown, Jasper van der Aart, Hilda van den Bos, Diana Carolina Johanna Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H Rabinowitz, Laila Ait Hassou, Saskia Litière, D Lucas Kerr, Lisa Tan, Gavin P Kelly, David Allan Moore, Matthew J Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R M Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M Blakely, Elza C de Bruin, Floris Foijer, Karen H Vousden, Trever G Bivona, null null, Robert Edward Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature communications 15 (1) (2024)
Katey S S Enfield, Emma C Colliver, Claudia S Y Lee, Alastair Magness, David Allan Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L Nye, Mary Green, Krijn K Dijkstra, Masako Shimato, Ayse U Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, TRACERx Consortium, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer discovery (2024)
Panagiotis Karras, James R M Black, Nicholas McGranahan, Jean-Christophe Marine
Decoding the interplay between genetic and non-genetic drivers of metastasis. Nature 629 (8012) (2024)
Katey S S Enfield, Emma C Colliver, Claudia S Y Lee, Alastair Magness, David Allan Moore, Monica Sivakumar, Kristiana Grigoriadis, Oriol Pich, Takahiro Karasaki, Philip S Hobson, Dina Levi, Selvaraju Veeriah, Clare Puttick, Emma L Nye, Mary Green, Krijn K Dijkstra, Masako Shimato, Ayse U Akarca, Teresa Marafioti, Roberto Salgado, Allan Hackshaw, null null, Mariam Jamal-Hanjani, Febe van Maldegem, Nicholas McGranahan, Benjamin Glass, Hanna Pulaski, Eric Walk, James L Reading, Sergio A Quezada, Crispin T Hiley, Julian Downward, Erik Sahai, Charles Swanton, Mihaela Angelova
Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer. Cancer discovery 14 (6) (2024)
Robert Edward Hynds, Ariana Huebner, David R Pearce, Mark S Hill, Ayse U Akarca, David Allan Moore, Sophia Ward, Kate H C Gowers, Takahiro Karasaki, Maise Al Bakir, Gareth A Wilson, Oriol Pich, Carlos Martínez-Ruiz, A S Md Mukarram Hossain, Simon P Pearce, Monica Sivakumar, Assma Ben Aissa, Eva Grönroos, Deepak P Chandrasekharan, Krishna K Kolluri, Rebecca Towns, Kaiwen Wang, Daniel E Cook, Leticia Bosshard-Carter, Cristina Naceur-Lombardelli, Andrew J Rowan, Selvaraju Veeriah, Kevin Litchfield, Philip A J Crosbie, Caroline Dive, Sergio A Quezada, Samuel M Janes, Mariam Jamal-Hanjani, Teresa Marafioti, null null, Nicholas McGranahan, Charles Swanton
Representation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models. Nature communications 15 (1) (2024)
Sebastijan Hobor, Maise Al Bakir, Crispin T Hiley, Marcin Skrzypski, Alexander M Frankell, Bjorn Bakker, Thomas B K Watkins, Aleksandra Markovets, Jonathan R Dry, Andrew P Brown, Jasper van der Aart, Hilda van den Bos, Diana Carolina Johanna Spierings, Dahmane Oukrif, Marco Novelli, Turja Chakrabarti, Adam H Rabinowitz, Laila Ait Hassou, Saskia Litière, D Lucas Kerr, Lisa Tan, Gavin P Kelly, David Allan Moore, Matthew J Renshaw, Subramanian Venkatesan, William Hill, Ariana Huebner, Carlos Martínez-Ruiz, James R M Black, Wei Wu, Mihaela Angelova, Nicholas McGranahan, Julian Downward, Juliann Chmielecki, Carl Barrett, Kevin Litchfield, Su Kit Chew, Collin M Blakely, Elza C de Bruin, Floris Foijer, Karen H Vousden, Trever G Bivona, null null, Robert Edward Hynds, Nnennaya Kanu, Simone Zaccaria, Eva Grönroos, Charles Swanton
Mixed responses to targeted therapy driven by chromosomal instability through p53 dysfunction and genome doubling. Nature communications 15 (1) (2024)
Ariana Huebner, James R M Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A Toledo
ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA. Genome medicine 15 (1) (2023)
Kevin W Ng, Jesse Boumelha, Katey S S Enfield, Jorge Almagro, Hongui Cha, Oriol Pich, Takahiro Karasaki, David A Moore, Roberto Salgado, Monica Sivakumar, George R Young, Miriam Molina-Arcas, Sophie de Carné Trécesson, Panayiotis Anastasiou, Annika Fendler, Lewis Au, Scott T C Shepherd, Carlos Martínez-Ruiz, Clare Puttick, James R M Black, Thomas B K Watkins, Hyemin Kim, Seohee Shim, Nikhil Faulkner, Jan Attig, Selvaraju Veeriah, Neil Magno, Sophia Ward, Alexander M Frankell, Maise Al Bakir, Emilia L Lim, Mark S Hill, Gareth A Wilson, Daniel E Cook, Nicolai Juul Birkbak, Axel Behrens, Nadia Yousaf, Sanjay Popat, Allan Hackshaw, null null, null null, Crispin T Hiley, Kevin Litchfield, Nicholas McGranahan, Mariam Jamal-Hanjani, James Larkin, Se-Hoon Lee, Samra Turajlic, Charles Swanton, Julian Downward, George Kassiotis
Antibodies against endogenous retroviruses promote lung cancer immunotherapy. Nature (2023)
Carlos Martínez-Ruiz, James R M Black, Clare Puttick, Mark S Hill, Jonas Demeulemeester, Elizabeth Larose Cadieux, Kerstin Thol, Thomas P Jones, Selvaraju Veeriah, Cristina Naceur-Lombardelli, Antonia Toncheva, Paulina Prymas, Andrew Rowan, Sophia Ward, Laura Cubitt, Foteini Athanasopoulou, Oriol Pich, Takahiro Karasaki, David Allan Moore, Roberto Salgado, Emma C Colliver, Carla Castignani, Michelle Dietzen, Ariana Huebner, Maise Al Bakir, Miljana Tanić, Thomas B K Watkins, Emilia L Lim, Ali M Al-Rashed, Danny Lang, James Clements, Daniel E Cook, Rachel Rosenthal, Gareth A Wilson, Alexander M Frankell, Sophie de Carné Trécesson, Philip East, Nnennaya Kanu, Kevin Litchfield, Nicolai Juul Birkbak, Allan Hackshaw, Stephan Beck, Peter Van Loo, Mariam Jamal-Hanjani, null null, Charles Swanton, Nicholas McGranahan
Genomic-transcriptomic evolution in lung cancer and metastasis. Nature (2023)
Lavinia Spain, Alexander Coulton, Irene Lobon, Andrew Rowan, Desiree Schnidrig, Scott T C Shepherd, Benjamin Shum, Fiona Byrne, Maria Goicoechea, Elisa Piperni, Lewis Au, Kim Edmonds, Eleanor Carlyle, Nikki Hunter, Alexandra Renn, Christina Messiou, Peta Hughes, Jaime Nobbs, Floris Foijer, Hilda van den Bos, Rene Wardenaar, Diana Carolina Johanna Spierings, Charlotte Spencer, Andreas Michael Schmitt, Zayd Tippu, Karla Lingard, Lauren Grostate, Kema Peat, Kayleigh Kelly, Sarah Sarker, Sarah Vaughan, Mary Mangwende, Lauren Terry, Denise Kelly, Jennifer Biano, Aida Murra, Justine Korteweg, Charlotte Lewis, Molly OFlaherty, Anne-Laure Cattin, Max Emmerich, Camille L Gerard, Husayn Ahmed Pallikonda, Joanna Lynch, Robert Mason, Aljosja Rogiers, Hang Xu, Ariana Huebner, Nicholas McGranahan, Maise Al Bakir, Jun Murai, Cristina Naceur-Lombardelli, Elaine Borg, Miriam Mitchison, David Allan Moore, Mary Falzon, Ian Proctor, Gordon W H Stamp, Emma L Nye, Kate Young, Andrew J S Furness, Lisa M Pickering, Ruby Stewart, Ula Mahadeva, Anna C Green, James M G Larkin, Kevin Litchfield, Charles Swanton, Mariam Jamal-Hanjani, Samra Turajlic
Late-stage metastatic melanoma emerges through a diversity of evolutionary pathways. Cancer discovery (2023)
Oliver Jonathan Ziff, Jacob Neeves, Jamie Mitchell, Giulia E Tyzack, Carlos Martínez-Ruiz, Raphaelle Luisier, Anob M Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J Boulton, Ammar Al Chalabi, Gavin P Kelly, Jack Humphrey, Rickie Patani
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology. Nature communications 14 (1) (2023)
Ariana Huebner, James R M Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A Toledo
ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA. Genome medicine 15 (1) (2023)
Oliver Jonathan Ziff, Jacob Neeves, Jamie Mitchell, Giulia E Tyzack, Carlos Martínez-Ruiz, Raphaelle Luisier, Anob M Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J Boulton, Ammar Al Chalabi, Gavin P Kelly, Jack Humphrey, Rickie Patani
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology. Nature communications 14 (1) (2023)
Christopher Abbosh, Alexander M Frankell, Thomas Harrison, Judit Kisistok, Aaron Garnett, Laura Johnson, Selvaraju Veeriah, Mike Moreau, Adrian Chesh, Tafadzwa L Chaunzwa, Jakob Weiss, Morgan R Schroeder, Sophia Ward, Kristiana Grigoriadis, Aamir Shahpurwalla, Kevin Litchfield, Clare Puttick, Dhruva Biswas, Takahiro Karasaki, James R M Black, Carlos Martínez-Ruiz, Maise Al Bakir, Oriol Pich, Thomas B K Watkins, Emilia L Lim, Ariana Huebner, David Allan Moore, Nadia Godin-Heymann, Anne L'Hernault, Hannah Bye, Aaron Odell, Paula Roberts, Fabio Gomes, Akshay J Patel, Elizabeth Manzano, Crispin T Hiley, Nicolas Carey, Joan Riley, Daniel E Cook, Darren Hodgson, Daniel Stetson, J Carl Barrett, Roderik M Kortlever, Gerard I Evan, Allan Hackshaw, Robert D Daber, Jacqueline A Shaw, Hugo J W L Aerts, Abel Licon, Josh Stahl, Mariam Jamal-Hanjani, null null, Nicolai Juul Birkbak, Nicholas McGranahan, Charles Swanton
Tracking early lung cancer metastatic dissemination in TRACERx using ctDNA. Nature (2023)
Takahiro Karasaki, David Allan Moore, Selvaraju Veeriah, Cristina Naceur-Lombardelli, Antonia Toncheva, Neil Magno, Sophia Ward, Maise Al Bakir, Thomas B K Watkins, Kristiana Grigoriadis, Ariana Huebner, Mark S Hill, Alexander M Frankell, Christopher Abbosh, Clare Puttick, Haoran Zhai, Francisco Gimeno-Valiente, Sadegh Saghafinia, Nnennaya Kanu, Michelle Dietzen, Oriol Pich, Emilia L Lim, Carlos Martínez-Ruiz, James R M Black, Dhruva Biswas, Brittany B Campbell, Claudia S Y Lee, Emma C Colliver, Katey S S Enfield, Sonya Hessey, Crispin T Hiley, Simone Zaccaria, Kevin Litchfield, Nicolai Juul Birkbak, Elizabeth Larose Cadieux, Jonas Demeulemeester, Peter Van Loo, Prasad S Adusumilli, Kay See Tan, Waseem Cheema, Francisco Sanchez-Vega, David R Jones, Natasha Rekhtman, William D Travis, Allan Hackshaw, Teresa Marafioti, Roberto Salgado, John P C Le Quesne, Andrew G Nicholson, null null, Nicholas McGranahan, Charles Swanton, Mariam Jamal-Hanjani
Evolutionary characterization of lung adenocarcinoma morphology in TRACERx. Nature medicine (2023)
Kristiana Grigoriadis, Ariana Huebner, Abigail Bunkum, Emma C Colliver, Alexander M Frankell, Mark S Hill, Kerstin Thol, Nicolai Juul Birkbak, Charles Swanton, Simone Zaccaria, Nicholas McGranahan
CONIPHER: a computational framework for scalable phylogenetic reconstruction with error correction. Nature protocols (2023)
Alexander M Frankell, Michelle Dietzen, Maise Al Bakir, Emilia L Lim, Takahiro Karasaki, Sophia Ward, Selvaraju Veeriah, Emma C Colliver, Ariana Huebner, Abigail Bunkum, Mark S Hill, Kristiana Grigoriadis, David Allan Moore, James R M Black, Wing Kin Liu, Kerstin Thol, Oriol Pich, Thomas B K Watkins, Cristina Naceur-Lombardelli, Daniel E Cook, Roberto Salgado, Gareth A Wilson, Chris Bailey, Mihaela Angelova, Robert Bentham, Carlos Martínez-Ruiz, Christopher Abbosh, Andrew G Nicholson, John P C Le Quesne, Dhruva Biswas, Rachel Rosenthal, Clare Puttick, Sonya Hessey, Claudia S Y Lee, Paulina Prymas, Antonia Toncheva, Jon Smith, Wei Xing, Jérôme Nicod, Gillian Price, Keith M Kerr, Babu Naidu, Gary M Middleton, Kevin G Blyth, Dean A Fennell, Martin D Forster, Siow Ming Lee, Mary Falzon, Madeleine Hewish, Michael J Shackcloth, Eric Lim, Sarah Benafif, Peter Russell, Ekaterini Boleti, Matthew G Krebs, Jason F Lester, Dionysis Papadatos-Pastos, Tanya Ahmad, Ricky M Thakrar, David Lawrence, Neal Navani, Sam M Janes, Caroline Dive, Fiona H Blackhall, Yvonne Summers, Judith Cave, Teresa Marafioti, Javier Herrero, Sergio A Quezada, Karl S Peggs, Roland F Schwarz, Peter Van Loo, Daniël M Miedema, Nicolai Juul Birkbak, Crispin T Hiley, Allan Hackshaw, Simone Zaccaria, null null, Mariam Jamal-Hanjani, Nicholas McGranahan, Charles Swanton
The evolution of lung cancer and impact of subclonal selection in TRACERx. Nature (2023)
Ariana Huebner, James R M Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A Toledo
ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA. Genome medicine 15 (1) (2023)
Ariana Huebner, James R M Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A Toledo
ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA. Genome medicine 15 (1) (2023)
Hanyun Zhang, Khalid AbdulJabbar, David Allan Moore, Ayse U Akarca, Katey S S Enfield, Mariam Jamal-Hanjani, Shan E Ahmed Raza, Selvaraju Veeriah, Roberto Salgado, Nicholas McGranahan, John P C Le Quesne, Charles Swanton, Teresa Marafioti, Yinyin Yuan
Spatial positioning of immune hotspots reflects the interplay between B and T cells in lung squamous cell carcinoma. Cancer research (2023)
Oliver Jonathan Ziff, Jacob Neeves, Jamie Mitchell, Giulia E Tyzack, Carlos Martínez-Ruiz, Raphaelle Luisier, Anob M Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J Boulton, Ammar Al Chalabi, Gavin P Kelly, Jack Humphrey, Rickie Patani
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology. Nature communications 14 (1) (2023)
William Hill, Emilia L Lim, Clare E Weeden, Claudia S Y Lee, Marcellus Augustine, Kezhong Chen, Feng-Che Kuan, Fabio Marongiu, Edward J Evans, David Allan Moore, Felipe S Rodrigues, Oriol Pich, Bjorn Bakker, Hongui Cha, Renelle Myers, Febe van Maldegem, Jesse Boumelha, Selvaraju Veeriah, Andrew Rowan, Cristina Naceur-Lombardelli, Takahiro Karasaki, Monica Sivakumar, Swapnanil De, Deborah R Caswell, Ai Nagano, James R M Black, Carlos Martínez-Ruiz, Min Hyung Ryu, Ryan D Huff, Shijia Li, Marie-Julie Favé, Alastair Magness, Alejandro Suarez-Bonnet, Simon Lawrence Priestnall, Margreet Lüchtenborg, Katrina Lavelle, Joanna Pethick, Steven Hardy, Fiona E McRonald, Meng-Hung Lin, Clara I Troccoli, Moumita Ghosh, York E Miller, Daniel T Merrick, Robert L Keith, Maise Al Bakir, Chris Bailey, Mark S Hill, Lao H Saal, Yilun Chen, Anthony M George, Christopher Abbosh, Nnennaya Kanu, Se-Hoon Lee, Nicholas McGranahan, Christine D Berg, Peter D Sasieni, Richard S Houlston, Clare Turnbull, Stephen Lam, Phillip Awadalla, Eva Grönroos, Julian Downward, Tyler Jacks, Christopher Carlsten, Ilaria Malanchi, Allan Hackshaw, Kevin Litchfield, null null, James DeGregori, Mariam Jamal-Hanjani, Charles Swanton
Lung adenocarcinoma promotion by air pollutants. Nature 616 (7955) (2023)
Oliver Jonathan Ziff, Jacob Neeves, Jamie Mitchell, Giulia E Tyzack, Carlos Martínez-Ruiz, Raphaelle Luisier, Anob M Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J Boulton, Ammar Al Chalabi, Gavin P Kelly, Jack Humphrey, Rickie Patani
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology. Nature communications 14 (1) (2023)
Ariana Huebner, James R M Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A Toledo
ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA. Genome medicine 15 (1) (2023)
Oliver Jonathan Ziff, Jacob Neeves, Jamie Mitchell, Giulia E Tyzack, Carlos Martínez-Ruiz, Raphaelle Luisier, Anob M Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J Boulton, Ammar Al Chalabi, Gavin P Kelly, Jack Humphrey, Rickie Patani
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology. Nature communications 14 (1) (2023)
Ariana Huebner, James R M Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A Toledo
ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA. Genome medicine 15 (1) (2023)
Ariana Huebner, James R M Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A Toledo
ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA. Genome medicine 15 (1) (2023)
Oliver Jonathan Ziff, Jacob Neeves, Jamie Mitchell, Giulia E Tyzack, Carlos Martínez-Ruiz, Raphaelle Luisier, Anob M Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J Boulton, Ammar Al Chalabi, Gavin P Kelly, Jack Humphrey, Rickie Patani
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology. Nature communications 14 (1) (2023)
Maise Al Bakir, Ariana Huebner, Carlos Martínez-Ruiz, Kristiana Grigoriadis, Thomas B K Watkins, Oriol Pich, David Allan Moore, Selvaraju Veeriah, Sophia Ward, Joanne Laycock, Diana Johnson, Andrew Rowan, Maryam Razaq, Mita Akther, Cristina Naceur-Lombardelli, Paulina Prymas, Antonia Toncheva, Sonya Hessey, Michelle Dietzen, Emma C Colliver, Alexander M Frankell, Abigail Bunkum, Emilia L Lim, Takahiro Karasaki, Christopher Abbosh, Crispin T Hiley, Mark S Hill, Daniel E Cook, Gareth A Wilson, Roberto Salgado, Emma Nye, Richard Kevin Stone, Dean A Fennell, Gillian Price, Keith M Kerr, Babu Naidu, Gary M Middleton, Yvonne Summers, Colin R Lindsay, Fiona H Blackhall, Judith Cave, Kevin G Blyth, Arjun Nair, Asia Ahmed, Magali N Taylor, Alexander James Procter, Mary Falzon, David Lawrence, Neal Navani, Ricky M Thakrar, Samuel M Janes, Dionysis Papadatos-Pastos, Martin D Forster, Siow Ming Lee, Tanya Ahmad, Sergio A Quezada, Karl S Peggs, Peter Van Loo, Caroline Dive, Allan Hackshaw, Nicolai Juul Birkbak, Simone Zaccaria, null null, Mariam Jamal-Hanjani, Nicholas McGranahan, Charles Swanton
The evolution of non-small cell lung cancer metastases in TRACERx. Nature (2023)
Oliver Jonathan Ziff, Jacob Neeves, Jamie Mitchell, Giulia E Tyzack, Carlos Martínez-Ruiz, Raphaelle Luisier, Anob M Chakrabarti, Nicholas McGranahan, Kevin Litchfield, Simon J Boulton, Ammar Al Chalabi, Gavin P Kelly, Jack Humphrey, Rickie Patani
Integrated transcriptome landscape of ALS identifies genome instability linked to TDP-43 pathology. Nature communications 14 (1) (2023)
Ariana Huebner, James R M Black, Francesca Sarno, Roberto Pazo, Ignacio Juez, Laura Medina, Rocio Garcia-Carbonero, Carmen Guillén, Jaime Feliú, Carolina Alonso, Carlota Arenillas, Ana Belén Moreno-Cárdenas, Helena Verdaguer, Teresa Macarulla, Manuel Hidalgo, Nicholas McGranahan, Rodrigo A Toledo
ACT-Discover: identifying karyotype heterogeneity in pancreatic cancer evolution using ctDNA. Genome medicine 15 (1) (2023)
Anna-Lena Meinhardt, Enkhtsetseg Munkhbaatar, Ulrike Höckendorf, Michelle Dietzen, Marta Dechant, Martina Anton, Anne Jacob, Katja Steiger, Wilko Weichert, Luka Brcic, Nicholas McGranahan, Caterina Branca, Thomas Kaufmann, Michael A Dengler, Philipp J Jost
The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner. Oncogene 41 (9) (2022)
Kerstin Thol, Piotr Pawlik, Nicholas McGranahan
Therapy sculpts the complex interplay between cancer and the immune system during tumour evolution. Genome medicine 14 (1) (2022)
Ming Chen, Runzhe Chen, Ying Jin, Jun Li, Xin Hu, Jianhua Zhang, Junya Fujimoto, Shawna Marie Hubert, Carl M Gay, Bo Zhu, Yanhua Tian, Nicholas McGranahan, Won-Chul Lee, Julie George, Xiao Hu, Yamei Chen, Meijuan Wu, Carmen Behrens, Chi-Wan Chow, Hoa H N Pham, Junya Fukuoka, Jia Wu, Edwin Roger Parra Cuentes, Latasha D Little, Curtis Gumbs, Xingzhi Song, Chang-Jiun Wu, Lixia Diao, Qi Wang, Robert Cardnell, Jianhua Zhang, Jing Wang, Xiuning Li, Don L Gibbons, John Victor Heymach, Jiun-Kae Jack Lee, William N William, Chao Cheng, Bonnie Glisson, Ignacio Wistuba, P Andrew Futreal, Roman K Thomas, Alexandre Reuben, Lauren Averett Byers, Jianjun Zhang
Cold and heterogeneous T cell repertoire is associated with copy number aberrations and loss of immune genes in small-cell lung cancer. Nature communications 12 (1) (2021)
James R M Black, Nicholas McGranahan
Genetic and non-genetic clonal diversity in cancer evolution. Nature reviews. Cancer 21 (6) (2021)
Antoine M Dujon, Athena Aktipis, Catherine Alix-Panabières, Sarah R Amend, Amy M Boddy, Joel S Brown, Jean-Pascal Capp, James DeGregori, Paul Ewald, Robert A Gatenby, Marco Gerlinger, Mathieu Giraudeau, Rodrigo K Hamede, Elsa Hansen, Irina Kareva, Carlo C Maley, Andriy Marusyk, Nicholas McGranahan, Michael J Metzger, Aurora M Nedelcu, Robert John Noble, Leonard Nunney, Kenneth J Pienta, Kornelia Polyak, Pascal Pujol, Andrew F Read, Benjamin Roche, Susanne Sebens, Eric Solary, Kateřina Staňková, Holly Swain Ewald, Frederic Thomas, Beata Ujvari
Identifying key questions in the ecology and evolution of cancer. Evolutionary applications 14 (4) (2021)
Robert Bentham, Kevin Litchfield, Thomas B K Watkins, Emilia L Lim, Rachel Rosenthal, Carlos Martínez-Ruiz, Crispin T Hiley, Maise Al Bakir, Roberto Salgado, David A Moore, Mariam Jamal-Hanjani, null null, Charles Swanton, Nicholas McGranahan
Using DNA sequencing data to quantify T cell fraction and therapy response. Nature 597 (7877) (2021)
Saioa López, Emilia L Lim, Stuart Horswell, Kerstin Haase, Ariana Huebner, Michelle Dietzen, Thanos P Mourikis, Thomas B K Watkins, Andrew Rowan, Sally M Dewhurst, Nicolai Juul Birkbak, Gareth A Wilson, Peter Van Loo, Mariam Jamal-Hanjani, null null, Charles Swanton, Nicholas McGranahan
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution. Nature genetics 52 (3) (2020)
Khalid AbdulJabbar, Shan E Ahmed Raza, Rachel Rosenthal, Mariam Jamal-Hanjani, Selvaraju Veeriah, Ayse Akarca, Tom Lund, David A Moore, Roberto Salgado, Maise Al Bakir, Luis Zapata, Crispin T Hiley, Leah Officer, Marco Sereno, Claire Rachel Wilson, Sherene Loi, Allan Hackshaw, Teresa Marafioti, Sergio A Quezada, Nicholas McGranahan, John Le Quesne, null null, Charles Swanton, Yinyin Yuan
Geospatial immune variability illuminates differential evolution of lung adenocarcinoma. Nature medicine 26 (7) (2020)
Alina Schenk, Saioa López, Maik Kschischo, Nicholas McGranahan
Germline ancestry influences the evolutionary disease course in lung adenocarcinomas. Evolutionary applications 13 (7) (2020)
Nicholas McGranahan, Charles Swanton
Neoantigen quality, not quantity. Science translational medicine 11 (506) (2020)
Thomas B K Watkins, Emilia L Lim, Marina Petkovic, Sergi Elizalde, Nicolai Juul Birkbak, Gareth A Wilson, David A Moore, Eva Grönroos, Andrew Rowan, Sally M Dewhurst, Jonas Demeulemeester, Stefan C Dentro, Stuart Horswell, Lewis Au, Kerstin Haase, Mickael Escudero, Rachel Rosenthal, Maise Al Bakir, Hang Xu, Kevin Litchfield, Wei-Ting Lu, Thanos P Mourikis, Michelle Dietzen, Lavinia Spain, George D Cresswell, Dhruva Biswas, Philippe Lamy, Iver Nordentoft, Katja Harbst, Francesc Castro Giner, Lucy R Yates, Franco Caramia, Fanny Jaulin, Cécile Vicier, Ian P M Tomlinson, Priscilla K Brastianos, Raymond J Cho, Boris C Bastian, Lars Dyrskjøt, Göran B Jönsson, Peter Savas, Sherene Loi, Peter J Campbell, Fabrice Andre, Nicholas M Luscombe, Neeltje Steeghs, Vivianne C G Tjan-Heijnen, Zoltan Szallasi, Samra Turajlic, Mariam Jamal-Hanjani, Peter Van Loo, Samuel F Bakhoum, Roland F Schwarz, Nicholas McGranahan, Charles Swanton
Pervasive chromosomal instability and karyotype order in tumour evolution. Nature 587 (7832) (2020)
Enkhtsetseg Munkhbaatar, Michelle Dietzen, Deepti Agrawal, Martina Anton, Moritz Jesinghaus, Melanie Boxberg, Nicole Pfarr, Pidassa Bidola, Sebastian Uhrig, Ulrike Höckendorf, Anna-Lena Meinhardt, Adam Wahida, Irina Heid, Rickmer F Braren, Ritu Mishra, Arne Warth, Thomas Muley, Patrina S P Poh, Xin Wang, Stefan Fröhling, Katja Steiger, Julia Slotta-Huspenina, Martijn van Griensven, Franz Pfeiffer, Sebastian Lange, Roland Rad, Magda Spella, Georgios T Stathopoulos, Juergen Ruland, Florian Bassermann, Wilko Weichert, Andreas Strasser, Caterina Branca, Mathias F Heikenwälder, Charles Swanton, Nicholas McGranahan, Philipp J Jost
MCL-1 gains occur with high frequency in lung adenocarcinoma and can be targeted therapeutically. Nature communications 11 (1) (2020)
Dhruva Biswas, Nicolai Juul Birkbak, Rachel Rosenthal, Crispin T Hiley, Emilia L Lim, Krisztian Papp, Stefan Boeing, Marcin Krzystanek, Dijana Djureinovic, Linnea La Fleur, Maria Greco, Balázs Döme, János Fillinger, Hans Brunnström, Yin Wu, David A Moore, Marcin Skrzypski, Christopher Abbosh, Kevin Litchfield, Maise Al Bakir, Thomas B K Watkins, Selvaraju Veeriah, Gareth A Wilson, Mariam Jamal-Hanjani, Judit Moldvay, Johan Botling, Arul M Chinnaiyan, Patrick Micke, Allan Hackshaw, Jiri Bartek, Istvan Csabai, Zoltan Szallasi, Javier Herrero, Nicholas McGranahan, Charles Swanton, null null
A clonal expression biomarker associates with lung cancer mortality. Nature medicine 25 (10) (2019)

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Nicholas McGranahan