Self-Contained Neuromusculoskeletal Arm Prostheses.
Max Ortiz-CatalanEnzo MastinuPaolo SassuOskar AszmannRickard BrånemarkPublished in: The New England journal of medicine (2020)
We report the use of a bone-anchored, self-contained robotic arm with both sensory and motor components over 3 to 7 years in four patients after transhumeral amputation. The implant allowed for bidirectional communication between a prosthetic hand and electrodes implanted in the nerves and muscles of the upper arm and was anchored to the humerus through osseointegration, the process in which bone cells attach to an artificial surface without formation of fibrous tissue. Use of the device did not require formal training and depended on the intuitive intent of the user to activate movement and sensory feedback from the prosthesis. Daily use resulted in increasing sensory acuity and effectiveness in work and other activities of daily life. (Funded by the Promobilia Foundation and others.).
Keyphrases
- end stage renal disease
- soft tissue
- induced apoptosis
- bone mineral density
- ejection fraction
- newly diagnosed
- physical activity
- randomized controlled trial
- chronic kidney disease
- peritoneal dialysis
- systematic review
- prognostic factors
- bone loss
- minimally invasive
- cell cycle arrest
- signaling pathway
- cell death
- robot assisted
- cell proliferation
- solid state
- pi k akt