Sodium-Glucose Cotransporter 2 Inhibitors and the Risk of Below-Knee Amputation: A Multicenter Observational Study.
Oriana Hoi Yun YuSophie Dell'AnielloBaiju R ShahVanessa C BrunettiJean-Marc DaigleMichael FralickAntonios DourosNianping HuSilvia Alessi-SeveriniAnat FisherShawn C BugdenPaul E RonksleyKristian B FilionPierre ErnstLisa M Lixnull nullPublished in: Diabetes care (2020)
In this large multicenter observational study, there was no association between SGLT2 inhibitor use and incident below-knee amputations among patients with type 2 diabetes compared with DPP-4 inhibitor use. While these findings provide some reassurance, studies with a longer duration of follow-up are needed to assess potential long-term effects.