Efficacy and tolerability of antipsychotic polypharmacy for schizophrenia spectrum disorders. A systematic review and meta-analysis of individual patient data.

Marc W H Lochmann van BennekomJoanna IntHoutHarm J GijsmanBerna B K AkdedeA Elif Anıl YağcıoğluThomas R E BarnesBritta GallingRalitza GueorguievaSiegfried KasperAnatoly KreininJimmi NielsenRené Ernst NielsenGary RemingtonEila Repo-TiihonenChristian Schmidt-KraepelinSaeed S ShaftiLe XiaoChristoph U CorrellRobbert-Jan Verkes

Published in: Schizophrenia research (2024)

APP was effective in severely psychotic patients with high baseline PANSS total scores and predominantly positive symptoms. This effect must be weighed against potential adverse effects.

Keyphrases

bipolar disorder
case report
open label
electronic health record
big data
sleep quality
randomized controlled trial
emergency department
machine learning
human health
risk assessment
adverse drug
placebo controlled
artificial intelligence
study protocol