Targeted Inhibition of P4HB Promotes Cell Sensitivity to Gemcitabine in Urothelial Carcinoma of the Bladder.
Xiaoming WangYun-Jin BaiFacai ZhangYubo YangDe-Chao FengAo LiZhiqiang YangDeng-Xiong LiYin TangXin WeiWuran WeiPing HanPublished in: OncoTargets and therapy (2020)
High P4HB expression was significantly correlated with poor prognosis in BC patients. Inhibition of P4HB by BAC decreased the cell proliferation ability and sensitized BC cells to GEM by activating apoptosis and the PERK/eIF2α/ATF4/CHOP pathways.
Keyphrases
- poor prognosis
- endoplasmic reticulum stress
- long non coding rna
- induced apoptosis
- cell cycle arrest
- cell proliferation
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- oxidative stress
- prognostic factors
- signaling pathway
- single cell
- cell death
- transcription factor
- peritoneal dialysis
- squamous cell carcinoma
- stem cells
- drug delivery
- endoplasmic reticulum