Exploring angiogenic pathways in breast cancer: Clinicopathologic correlations and prognostic implications based on gene expression profiles from a large-scale genomic dataset.

Nehad M Ayoub Salam Sardiah Qusai Y Al-ShareMohammad S Alkader

Published in: PloS one (2024)

In this dataset of patients with breast cancer, the expression levels of 8 different pro-angiogenic genes revealed remarkable differences in terms of their association with clinicopathologic tumor characteristics and prognosis. The expression of ANGPTs and PDGFs was associated with adverse tumor features, worse prognosis, and reduced survival in patients. Targeting ANGPTs and PDGF pathways could provide new insights for effective anti-angiogenic drugs in breast cancer.

Keyphrases

gene expression
poor prognosis
end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
binding protein
single cell
copy number
smooth muscle
patient reported outcomes
vascular smooth muscle cells
young adults
electronic health record