Human Astrovirus VA1 Encephalitis in Pediatric Patients With Cancer: Report of 2 Cases and Review of the Literature.
Sakshi BamiJennifer HidingerArshia MadniVirginia HargestStacey Schultz-CherryValerie CortezShane J CrossDeborah A WardRandall T HaydenJeffrey RubnitzChing-Hon PuiRaja B KhanDiego R HijanoPublished in: Journal of the Pediatric Infectious Diseases Society (2022)
Novel human astroviruses (HAstVs) have recently been implicated as rare causes of fatal encephalitis in immunocompromised patients, for which there is no proven treatment. We report 2 cases from our institution in which HAstV-VA1 was detected in the cerebrospinal fluid by metagenomic next-generation sequencing after the initial evaluation revealed no etiology.
Keyphrases
- endothelial cells
- cerebrospinal fluid
- end stage renal disease
- induced pluripotent stem cells
- newly diagnosed
- pluripotent stem cells
- chronic kidney disease
- prognostic factors
- single cell
- patient reported outcomes
- young adults
- intensive care unit
- combination therapy
- extracorporeal membrane oxygenation
- microbial community
- anaerobic digestion
- circulating tumor cells
- circulating tumor