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Porous Titanium Scaffolds Fabricated by Metal Injection Moulding for Biomedical Applications.

Ali Dehghan-ManshadiYunhui ChenZhiming ShiMichael J BerminghamDavid StJohnMatthew Simon DarguschMa Qian
Published in: Materials (Basel, Switzerland) (2018)
Biocompatible titanium scaffolds with up to 40% interconnected porosity were manufactured through the metal injection moulding process and the space holder technique. The mechanical properties of the manufactured scaffold showed a high level of compatibility with those of the cortical human bone. Sintering at 1250 °C produced scaffolds with 36% porosity and more than 90% interconnected pores, a compressive yield stress of 220 MPa and a Young's modulus of 7.80 GPa, all suitable for bone tissue engineering. Increasing the sintering temperature to 1300 °C increased the Young's modulus to 22.0 GPa due to reduced porosity, while reducing the sintering temperature to 1150 °C lowered the yield stress to 120 MPa, indicative of insufficient sintering. Electrochemical studies revealed that samples sintered at 1150 °C have a higher corrosion rate compared with those at a sintering temperature of 1250 °C. Overall, it was concluded that sintering at 1250 °C yielded the most desirable results.
Keyphrases
  • tissue engineering
  • bone mineral density
  • endothelial cells
  • gold nanoparticles
  • ultrasound guided
  • ionic liquid
  • middle aged
  • single cell
  • bone loss
  • bone regeneration
  • molecularly imprinted
  • pluripotent stem cells