Murine cadherin-6 mediates thrombosis in vivo in a platelet-independent manner.

Emma G BouckMaria de la FuenteElizabeth R ZunicaWei LiMichele M MumawMarvin T Nieman

Published in: Research and practice in thrombosis and haemostasis (2020)

Cadherin-6 plays an essential role in thrombosis in vivo. However, cadherin-6 is not expressed on murine platelets. These data are in contrast to human platelets, which express a functional cadherin-6/catenin complex. The essential, platelet-independent role for cadherin-6 in hemostasis may allow it to be an effective and safe therapeutic target.

Keyphrases

cell adhesion
cell migration
pulmonary embolism
endothelial cells
magnetic resonance
cell proliferation
epithelial mesenchymal transition
electronic health record
signaling pathway
artificial intelligence
pluripotent stem cells