Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice.
Katharine M von HerrmannFaith L AndersonEileen M MartinezAlison L YoungMatthew C HavrdaPublished in: Journal of neuroinflammation (2020)
Dopaminergic neurons have the potential to accumulate NLRP3 inflammasome activators with age, including reactive oxygen species, dopamine metabolites, and misfolded proteins. Results indicate the Nlrp3 locus is active in dopaminergic neurons in aging mice, and that the hyperactive Nlrp3L351P allele can drive neuroinflammatory changes in association with progressive behavioral deficits. Findings suggest neuronal NLRP3 inflammasome activity may contribute to neuroinflammation observed during normal aging and the progression of neurologic disorders.
Keyphrases
- nlrp inflammasome
- traumatic brain injury
- reactive oxygen species
- multiple sclerosis
- high fat diet induced
- spinal cord
- lipopolysaccharide induced
- cerebral ischemia
- lps induced
- poor prognosis
- cognitive impairment
- ms ms
- type diabetes
- inflammatory response
- uric acid
- insulin resistance
- brain injury
- wild type
- climate change
- spinal cord injury
- subarachnoid hemorrhage
- binding protein