Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent.
Sidnee L HedrickDan LuoSophia KaskaKumar Kulldeep NiloyKaren JacksonRupam SarmaJamie HornCaroline BaynardMarkos LeggasEduardo R ButelmanMary Jeanne KreekThomas Edward PrisinzanoPublished in: Journal of biomedical science (2021)
Methods have been developed that have utility to identify enhanced rescue agents for the treatment of OIRD. Analogue 29, possessing potent MOR antagonist activity in vitro and in vivo, provides a promising lead in our search for an enhanced synthetic opioid rescue agent.