Design, synthesis, and preliminary evaluation of a potential synthetic opioid rescue agent.

Sidnee L HedrickDan LuoSophia KaskaKumar Kulldeep NiloyKaren JacksonRupam SarmaJamie HornCaroline BaynardMarkos LeggasEduardo R ButelmanMary Jeanne KreekThomas Edward Prisinzano

Published in: Journal of biomedical science (2021)

Methods have been developed that have utility to identify enhanced rescue agents for the treatment of OIRD. Analogue 29, possessing potent MOR antagonist activity in vitro and in vivo, provides a promising lead in our search for an enhanced synthetic opioid rescue agent.

Keyphrases

chronic pain
pain management
anti inflammatory
human health
risk assessment
climate change