Increased Calcitonin Gene-Related Peptide Expression in DRG and Nerve Fibers Proliferation Caused by Nonunion Fracture in Rats.
Yusuke KasaiKoji AsoMasashi IzumiHiroyuki WadaJunpei DanYoshinori SatakeToru MorimotoMasahiko IkeuchiPublished in: Journal of pain research (2021)
Increased CGRP expression in DRG cells and abnormal nerve proliferation secondary to prolonged inflammation could lead to persistent pain after bone fracture. In clinical practice, early achievement of bone union may minimize the development of persistent pain after fractures.
Keyphrases
- poor prognosis
- chronic pain
- clinical practice
- signaling pathway
- induced apoptosis
- pain management
- bone mineral density
- neuropathic pain
- oxidative stress
- binding protein
- soft tissue
- peripheral nerve
- cell cycle arrest
- bone regeneration
- genome wide
- spinal cord injury
- gene expression
- endoplasmic reticulum stress
- transcription factor
- drug induced