Deficiency of plasminogen activator inhibitor-2 results in accelerated tumor growth.
Randal J WestrickLisa Payne RøjkjaerAngela Y YangMichael H RohAmy E SiebertDavid GinsburgPublished in: Journal of thrombosis and haemostasis : JTH (2020)
Our results suggest that PAI-2 deficiency increases susceptibility to spontaneous tumorigenesis in the mouse, and demonstrate that SerpinB2 expression derived from a nonhematopoietic compartment is a key host factor in the regulation of tumor growth in both the B16 melanoma and Lewis lung carcinoma models.