Down-regulation of the brain-specific cell-adhesion molecule contactin-3 in tuberous sclerosis complex during the early postnatal period.
Anatoly KorotkovMark J LuinenburgAlessia RomagnoloTill S ZimmerJackelien van ScheppingenAnika BongaartsDiede W M BroekaartJasper J AninkCaroline MijnsbergenFloor E JansenWim van HeckeWim G SplietPeter C van RijenMartha FeuchtJohannes A HainfellnerPavel KrsekJosef ZamecnikPeter B CrinoKatarzyna KotulskaLieven LagaeAnna C JansenDavid J KwiatkowskiSergiusz JozwiakPaolo CuratoloAngelika MühlebnerErwin A van VlietJames D MillsEleonora AronicaPublished in: Journal of neurodevelopmental disorders (2022)
Our data show a lower expression of contactin-3 in cortical tubers of TSC patients during early postnatal period as compared to controls, which may affect normal brain development and might contribute to neuropsychiatric co-morbidities observed in patients with TSC.
Keyphrases
- cell adhesion
- end stage renal disease
- preterm infants
- resting state
- white matter
- ejection fraction
- poor prognosis
- chronic kidney disease
- peritoneal dialysis
- functional connectivity
- prognostic factors
- cerebral ischemia
- electronic health record
- multiple sclerosis
- machine learning
- patient reported outcomes
- brain injury
- deep learning
- subarachnoid hemorrhage
- patient reported