Fuelling the mechanisms of asthma: Increased fatty acid oxidation in inflammatory immune cells may represent a novel therapeutic target.

Amir A Al-KhamiM A GhonimL Del ValleS V IbbaL ZhengK PyakurelS C OkpechiJ GarayD WyczechowskaM D Sanchez-PinoP C RodriguezA H BoularesA C Ochoa

Published in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2017)

These novel observations suggest that allergic airway inflammation increases FAO in inflammatory cells to support the production of cytokines, chemokines, and other factors important in the development of asthma. Inhibition of FAO by re-purposing existing drugs approved for the treatment of heart disease may provide a novel therapeutic approach for the treatment of asthma.

Keyphrases

chronic obstructive pulmonary disease
lung function
allergic rhinitis
fatty acid
oxidative stress
induced apoptosis
hydrogen peroxide
nitric oxide
cell cycle arrest
cell death
endoplasmic reticulum stress
air pollution
drug induced
pi k akt