Immune profiling of pituitary tumors reveals variations in immune infiltration and checkpoint molecule expression.
Yu MeiWenya Linda BiJames Paul AgoliaChangchen HuAlexandra M Giantini LarsenDavid M MeredithSally Al AbdulmohsenTejus BaleGavin P DunnMalak AbedalthagafiIan F DunnPublished in: Pituitary (2021)
Immune cell infiltration and checkpoint regulator expression vary depending on functional status and presence of pituitary tumor initiating cells. Functional tumors may have a particularly immunosuppressive microenvironment. Further studies of immune checkpoint blockade of pituitary tumors, particularly functional tumors, are warranted, though combination therapy may be required.