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Immune profiling of pituitary tumors reveals variations in immune infiltration and checkpoint molecule expression.

Yu MeiWenya Linda BiJames Paul AgoliaChangchen HuAlexandra M Giantini LarsenDavid M MeredithSally Al AbdulmohsenTejus BaleGavin P DunnMalak AbedalthagafiIan F Dunn
Published in: Pituitary (2021)
Immune cell infiltration and checkpoint regulator expression vary depending on functional status and presence of pituitary tumor initiating cells. Functional tumors may have a particularly immunosuppressive microenvironment. Further studies of immune checkpoint blockade of pituitary tumors, particularly functional tumors, are warranted, though combination therapy may be required.
Keyphrases
  • combination therapy
  • poor prognosis
  • dna damage
  • cell cycle
  • stem cells
  • induced apoptosis
  • growth hormone
  • binding protein
  • cell cycle arrest
  • cell proliferation
  • signaling pathway