Immunomodulatory/inflammatory effects of geopropolis produced by Melipona fasciculata Smith in combination with doxorubicin on THP-1 cells.

Lucas Pires Garcia OliveiraFernanda Lopes ConteEliza de Oliveira CardosoBruno José ContiKarina Basso SantiagoMarjorie de Assis GolimMaria Teresa CruzJosé Maurício Sforcin

Published in: The Journal of pharmacy and pharmacology (2016)

GEO exerted a pro-inflammatory profile by increasing TLR-4 and CD80 expression and TNF-α production, favouring the activation of the immune/inflammatory response. GEO + DOX did not affect cell viability and presented an immunomodulatory action. Lower concentrations of DOX combined to GEO could be used in cancer patients, avoiding side effects and benefiting from the biological properties of GEO.

Keyphrases

inflammatory response
induced apoptosis
toll like receptor
poor prognosis
lipopolysaccharide induced
rheumatoid arthritis
lps induced
oxidative stress
immune response
drug delivery
signaling pathway
long non coding rna
cell death
pi k akt