A high HIV-1 strain variability in London, UK, revealed by full-genome analysis: Results from the ICONIC project.

Gonzalo YebraDan FramptonTiziano Gallo CassarinoJade RaffleJonathan HubbR Bridget FernsLaura WatersC Y William TongZisis KozlakidisAndrew HaywardPaul KellamDeenan PillayDuncan ClarkEleni NastouliAndrew J Leigh Brownnull null

Published in: PloS one (2018)

The initial analysis of genome sequences detected substantial hidden variability in the London HIV epidemic. Analysing full genome sequences, as opposed to only PR+RT, identified previously undetected recombinants. It provided a more reliable description of CRFs (that would be otherwise misclassified) and transmission clusters.

Keyphrases

antiretroviral therapy
hiv positive
hiv infected
hiv testing
human immunodeficiency virus
hepatitis c virus
hiv aids
genome wide
men who have sex with men
cross sectional
dna methylation
gene expression