Balanced crystalloids versus isotonic saline in pediatric sepsis: a comprehensive systematic review and meta-analysis.

Asmaa MhannaAzizullah BeranOmar SrourMohammed MhannaAhmad AssalyAbdelrahman ElsayedNicholas G HorenRagheb Assaly

Published in: Proceedings (Baylor University. Medical Center) (2024)

Our meta-analysis demonstrates that using BC in pediatric sepsis is associated with reduced mortality, AKI, and hyperchloremia rates compared to IS, while maintaining similar hospital and PICU LOS. Large-scale randomized controlled trials are needed to validate these findings.

Keyphrases

acute kidney injury
systematic review
intensive care unit
septic shock
meta analyses
randomized controlled trial
cardiovascular events
risk factors
emergency department
cardiovascular disease
acute care
type diabetes
clinical trial
case control