Targeted therapies in HER2-positive breast cancer with receptor-redirected Arazyme-linker-Herceptin as a novel fusion protein.

Farideh RahmaniHatef AjoudanifarNazila Arbab SoleimaniAbbas Ali Imani Fooladi

Published in: Breast cancer (Tokyo, Japan) (2024)

The findings of this study demonstrated that the Arazyme-linker-Herceptin induced apoptosis and decreased metastatic genes in SKBR3 cells; however, further research is required to confirm the effectiveness of the fusion protein.

Keyphrases

induced apoptosis
endoplasmic reticulum stress
positive breast cancer
signaling pathway
oxidative stress
squamous cell carcinoma
randomized controlled trial
small cell lung cancer
systematic review
gene expression
dna methylation
transcription factor
cell proliferation
binding protein