A sensitive liquid chromatography method for analysis of propofol in small volumes of neonatal blood.

Bing Qi Johan Nicolai Anne Smits Tom De Vocht Neel Deferm Pieter Van Brantegem Karel Allegaert Pieter Annaert

Published in: Journal of clinical pharmacy and therapeutics (2019)

A minimal volume (0.2 mL) of blood from neonates is required for the determination of propofol with this method. The method can be used to support the quantification of propofol drug concentrations for pharmacokinetic studies in the neonatal population.

Keyphrases

liquid chromatography
mass spectrometry
emergency department
solid phase extraction
high resolution mass spectrometry
tandem mass spectrometry
preterm infants
low birth weight
simultaneous determination
adverse drug
drug induced